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Whey Protein Concentrate as a Tryptophan-Based Nutritional Intervention for Premenstrual Dysphoric Disorder (PMDD): A
1Functional Nutrition Consultant and Registered Dietitian, Bakersfield, CA, USA.
Introduction:
Premenstrual dysphoric disorder (PMDD) is a hormone-sensitive mood disorder characterized by cyclical emotional and functional impairment in the luteal phase. Serotonergic dysregulation contributes to its pathophysiology.
Case Presentation:
A 38-year-old registered dietitian with clinically diagnosed PMDD consumed 5 tablespoons of whey protein concentrate (WPC) blended into a carbohydrate-rich smoothie daily for 8 days before menstruation, across 3 consecutive cycles.
Outcomes:
The subject perceived substantial symptom relief (~ 80-95%), compared to her prior cycles and years of consistent symptoms. No adverse effects were reported.
Discussion:
WPC provides a food-based source of tryptophan; co-ingestion with carbohydrates enhances tryptophan transport into the brain by increasing the Trp/LNAA ratio.
Conclusion:
WPC may offer an effective and well-tolerated nutritional intervention for PMDD. Controlled trials are warranted.
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