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Preparation of 6-aminocyclohepta-2,4-dien-1-one Derivatives via Tricarbonyltroponeiron
Published on: August 12, 2019
Antischistosomal activity of imidazolidine-2,4-dione derivatives
Anna Jaromin1, Anna Czopek2, Thainá R Teixeira3
1Department of Lipids and Liposomes, Faculty of Biotechnology, University of Wrocław, Wrocław, Poland.
Abstract:
Schistosomiasis is a neglected tropical disease with limited treatment options and growing concerns over praziquantel resistance. We evaluated a series of 12 synthetic compounds for antiparasitic activity against Schistosoma mansoni adult worms in vitro. Isoindole-1,3-dione derivatives were inactive, whereas four imidazolidine-2,4-dione derivatives displayed selective antischistosomal activity with low cytotoxicity in mammalian cells. These findings highlight imidazolidine-2,4-dione as a promising scaffold for the development of new therapeutic agents against schistosomiasis.
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