T-cell lymphoblastic lymphoma presenting with type B lactic acidosis and acute kidney injury in an adolescent
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View abstract on PubMed
Summary
This summary is machine-generated.Pediatric acute kidney injury (AKI) can rarely stem from T-cell lymphoblastic lymphoma infiltration. Prompt diagnosis via kidney biopsy and chemotherapy are crucial for treating this rare cause of AKI and lactic acidosis in children.
Area Of Science
- Pediatric Nephrology
- Pediatric Hematology-Oncology
- Oncology
Background
- Acute kidney injury (AKI) in children is a significant cause of illness and death, often linked to dehydration, sepsis, or toxic exposures.
- While uncommon, hematologic malignancies can infiltrate the kidneys, leading to AKI.
Purpose Of The Study
- To report a rare case of pediatric AKI caused by direct renal infiltration of T-cell lymphoblastic lymphoma.
- To highlight the association between unexplained lactic acidosis, nephromegaly, and hematologic malignancy in pediatric AKI.
Main Methods
- Case report of a 13-year-old boy with AKI, metabolic acidosis, and hyperlactatemia.
- Diagnostic workup included imaging studies and kidney biopsy.
- Treatment involved chemotherapy.
Main Results
- Kidney biopsy revealed diffuse renal infiltration by T-cell lymphoblastic lymphoma.
- Metabolic findings indicated type B lactic acidosis, attributed to the Warburg effect.
- Lactate levels normalized rapidly after initiating chemotherapy.
Conclusions
- Hematologic malignancy should be considered in pediatric AKI cases with unexplained lactic acidosis and nephromegaly.
- Early recognition, kidney biopsy, and prompt oncologic treatment are vital for improved outcomes in such cases.
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