Related Experiment Video

Updated: Jan 28, 2026

Administration of Δ9-Tetrahydrocannabinol (THC) in Adolescent and Adult Mice
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Administration of Δ9-Tetrahydrocannabinol (THC) in Adolescent and Adult Mice

Published on: August 1, 2025

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Redefining Treatment Paradigms for Glioma in Adolescents and Young Adults: Population-Based Evidence for Molecular

Shanqiang Qu1,2,3,4, Qiuming Pan1,2,3,4, Xin Zhang3,5

  • 1Department of Neurosurgery, Nanfang Hospital, Southern Medical University, Guangzhou, The People's Republic of China.

Clinical Cancer Research : an Official Journal of the American Association for Cancer Research
|January 26, 2026
PubMed
Abstract

Insights

Adolescent and young adult (AYA) gliomas show distinct molecular profiles, with pediatric-type alterations prevalent. Molecular classification, not age, should guide AYA glioma treatment strategies for better outcomes.

Area of Science:

  • Neuro-oncology
  • Molecular pathology
  • Genomics

Background:

  • Gliomas are a significant cause of cancer death in adolescents and young adults (AYA).
  • The molecular landscape of AYA gliomas is not fully understood.
  • Understanding these molecular differences is crucial for targeted therapies.

Purpose of the Study:

  • To characterize the molecular landscape of primary gliomas in AYA patients.
  • To integrate multi-omics data for comprehensive analysis.
  • To identify distinct molecular profiles between adult-type and pediatric-type gliomas in AYA.

Main Methods:

  • Recruitment of patients with histopathologically diagnosed primary gliomas.
  • Collection of clinical, imaging, histopathological, and genomic data.
  • Evaluation of correlations between clinicopathological features, molecular characteristics, anatomical heterogeneity, and prognosis.

Main Results:

  • Adult-type gliomas predominated (66.2%), but pediatric-type gliomas were also present (23.6%).
  • Pediatric-type gliomas showed frequent H3.3, TP53, and BRAF mutations, while adult-type had IDH and TP53 alterations.
  • H3.3 K27M-mutant high-grade gliomas had the poorest prognosis (16 months median survival), while BRAF-driven low-grade gliomas had favorable outcomes.

Conclusions:

  • Molecular classification, not age, should guide treatment strategies for AYA gliomas.
  • Adult-type and pediatric-type gliomas in AYA patients have distinct biological and driver profiles.
  • Significant molecular-anatomical heterogeneity exists in AYA gliomas, with specific regions enriched for molecular signatures.

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