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MAGIC: Study Design and Rationale for the Phase 2 Clinical Trial of Faricimab for Non-Proliferative Diabetic

Avery W Zhou1, Ryan A Sahraravand1, Liisa M Baumann1

  • 1Retina Consultants of Texas, Houston, Texas, USA.

Ophthalmologica. Journal International D'Ophtalmologie. International Journal of Ophthalmology. Zeitschrift Fur Augenheilkunde
|January 26, 2026
PubMed

Insights

The MAGIC trial investigates faricimab

Area of Science:

  • Ophthalmology
  • Diabetic Retinopathy Research
  • Clinical Trials

Background:

  • Non-proliferative diabetic retinopathy (NPDR) can lead to vision loss.
  • Retinal non-perfusion (RNP) is a key indicator of NPDR progression.
  • Understanding RNP progression and treatment effects is crucial.

Purpose of the Study:

  • To describe the design and rationale of the MAGIC trial (NCT05681884).
  • To assess changes in retinal non-perfusion (RNP) in patients with NPDR.
  • To evaluate the impact of faricimab on RNP progression.

Main Methods:

  • Phase 2, prospective, randomized, multicenter, open-label trial.
  • Adults with NPDR and substantial RNP (> 5 disc areas) were enrolled.
  • Patients received either intravitreal faricimab or observation, with treatment arms switching at 48 weeks.

Main Results:

  • Recruitment occurred from May 2023 to May 2024.
  • The study design aims to maximize detection of faricimab's impact on RNP.
  • Novel assessments like contrast sensitivity and DARC analysis are included.

Conclusions:

  • The MAGIC trial is a randomized study of RNP progression in NPDR.
  • It evaluates both the natural history of RNP and the effect of faricimab.
  • The trial incorporates innovative assessments of retinal physiology and function.
Keywords:
FaricimabNon-proliferative diabetic retinopathyRetinal nonperfusionStudy design

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