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Updated: Jan 28, 2026

Synthesis and Characterization of 1,2-Dithiolane Modified Self-Assembling Peptides
Published on: August 20, 2018
Orthogonal Electrochemical Amine Deprotection: Toward Sustainable Strategies for Peptide Synthesis
Esteban Suárez-Picado1, Saurabh K Ahirwar1, Lara R Malins1
1Research School of Chemistry and Australian Research Council Centre of Excellence for Innovations in Peptide and Protein Science, Australian National University, Canberra, ACT 2601, Australia.
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Deprotection steps employed in peptide synthesis often require harsh conditions and excess reagents, limiting substrate compatibility and sustainability. Electrochemically cleavable protecting groups (e-PGs) offer an attractive alternative. Here, we report the use of 1,3-dithiane-based e-PGs for orthogonal protection of lysine ε-amines in peptide synthesis. Under constant potential electrolysis, deprotection proceeds selectively and orthogonally to other common amino acid protecting groups (Alloc, Boc, Dde, Fmoc, Trt, Pbf, tBu), highlighting potential applications in sustainable peptide synthesis.
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