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Updated: Jan 28, 2026
07:02
Identifying Dysregulated Genes Induced by Kaposi's Sarcoma-associated Herpesvirus KSHV
Published on: September 14, 2010
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Improved screening for pulmonary Kaposi sarcoma in a low-resource setting
Margaret Z Borok1, Suzanne Fiorillo2, Felix Manyeruke1
1University of Zimbabwe, Faculty of Medicine and Health Sciences, Harare, Zimbabwe.
AIDS (London, England)
|January 26, 2026
Summary
Diagnosing pulmonary Kaposi sarcoma (KS) in low-resource settings is challenging. A combination of clinical assessments improved screening accuracy for pulmonary KS in HIV-associated KS patients.
Area of Science:
- Oncology
- Infectious Diseases
- Pulmonology
Background:
- Pulmonary involvement is common in advanced Kaposi sarcoma (KS), but diagnosis is difficult in resource-limited settings.
- HIV-associated KS presents diagnostic challenges, particularly for lung involvement.
- Accurate screening for pulmonary KS is crucial for timely intervention.
Purpose of the Study:
- To evaluate clinical assessments for improving the screening of pulmonary KS.
- To identify key diagnostic indicators for pulmonary KS in a low-resource setting.
Main Methods:
- A longitudinal cohort study of 181 HIV-associated KS patients in Zimbabwe (2016-2018).
- Included physical exams, chest X-rays, pulmonary function tests, and bronchoscopy with cultures.
- Machine learning models iteratively identified important clinical assessments for predicting pulmonary KS.
Main Results:
- Pulmonary KS prevalence was 62.4% among patients with cutaneous KS.
- Tuberculosis (TB) and bacterial/fungal pneumonia prevalence were 9.4% each.
- A model using seven clinical assessments achieved an AUROC of 0.70 for predicting pulmonary KS.
Conclusions:
- Pulmonary KS remains a significant health issue in Zimbabwe.
- A combination of clinical assessments can enhance pulmonary KS screening in resource-limited environments.
- Improved screening strategies are needed for pulmonary KS in affected populations.
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