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Photodynamic therapy for colorectal cancer: A bibliometric and visualization analysis (1986-2025)

Xin Wen1, Jiayan Liu1, Wenbin Zhao1

  • 1West China-California Research Center for Predictive Intervention Medicine, Department of Dermatology, West China Hospital, Sichuan University, Chengdu 610041, China.

Photodiagnosis and Photodynamic Therapy
|January 26, 2026
PubMed
Abstract

Insights

Photodynamic therapy (PDT) for colorectal cancer (CRC) research is growing, with China and the US leading. While promising, clinical use of PDT for CRC is still developing.

Area of Science:

  • Oncology
  • Medical Technology
  • Biomedical Research

Background:

  • Photodynamic therapy (PDT) is a promising minimally invasive treatment for colorectal cancer (CRC).
  • PDT offers localized cytotoxicity and potential immune activation for CRC.
  • A comprehensive overview of the global research landscape for PDT in CRC is needed.

Purpose of the Study:

  • To systematically assess global trends in PDT for CRC research.
  • To analyze collaborative networks, influential contributors, and the current research status.
  • To map the research landscape using bibliometric analysis.

Main Methods:

  • Bibliometric analysis of 828 publications from 1986 to April 2025.
  • Data retrieved from Web of Science Core Collection.
  • VOSviewer and CiteSpace used for trend, network, and keyword analysis.

Main Results:

  • Global research on PDT for CRC has steadily increased since 2015.
  • China and the United States are the most prolific contributors.
  • Enhanced endoscopic visualization improves lesion localization and light delivery in PDT for CRC.

Conclusions:

  • PDT research for CRC is rapidly expanding with increasing interdisciplinary integration.
  • Clinical translation of PDT for CRC remains in the early stages.
  • This analysis highlights key contributors and themes in PDT for CRC research.
Keywords:
Adjuvant therapyBibliometric analysisColorectal cancerEndoscopyPhotodynamic therapy

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