Related Experiment Video

Updated: Jan 28, 2026

Author Spotlight: Characterizing Porous Materials for Aiding the Development of Robust Metal-Organic Frameworks with Adsorption Behavior
06:45

Author Spotlight: Characterizing Porous Materials for Aiding the Development of Robust Metal-Organic Frameworks with Adsorption Behavior

Published on: March 8, 2024

9.8K

Adsorption of Blood Creatinine on a Heparin-Functionalized Surface of Copper-Based Metal-Organic Frameworks

Zhenyu Gui1, Xiaoda Yang1, Hao Chen2

  • 1College of Materials and Textile Engineering, Jiaxing University, Jiaxing, China.

Therapeutic Apheresis and Dialysis : Official Peer-Reviewed Journal of the International Society for Apheresis, the Japanese Society for Apheresis, the Japanese Society for Dialysis Therapy
|January 26, 2026
PubMed

Insights

Heparin-functionalized copper-based metal-organic frameworks (CuMOFs-Hep) efficiently remove creatinine, a key marker in chronic kidney disease (CKD). This new adsorbent shows promise for blood purification with improved hemocompatibility.

Area of Science:

  • Materials Science
  • Biomedical Engineering
  • Nanotechnology

Background:

  • Creatinine accumulation is a significant concern in chronic kidney disease (CKD), negatively impacting patient outcomes.
  • Developing effective methods for creatinine removal is crucial for improving the quality of life for CKD patients.

Purpose of the Study:

  • To develop and characterize heparin-functionalized copper-based metal-organic frameworks (CuMOFs-Hep) for enhanced creatinine removal.
  • To evaluate the hemocompatibility and biosafety of the developed CuMOFs-Hep for blood purification applications.

Main Methods:

  • CuMOFs were synthesized and functionalized with heparin using APTES bridging.
  • Characterization involved XRD, SEM, FTIR, XPS, and zeta potential measurements.
  • Creatinine adsorption was assessed in simulated CKD serum and patient blood, with biosafety evaluated via Cu2+ leaching and platelet assays.

Main Results:

  • Heparinization significantly increased the maximum creatinine adsorption capacity to 267.8 mg/g, a 68.7% improvement.
  • Rapid creatinine clearance was observed, achieving 65.9% removal in 30 minutes and 75.0% in 2 hours.
  • In patient blood, CuMOFs-Hep reduced creatinine levels by 80.9% while significantly decreasing copper ion leaching and platelet activation.

Conclusions:

  • CuMOFs-Hep demonstrate efficient and low-leaching creatinine adsorption capabilities in clinically relevant settings.
  • The material exhibits promising potential as an effective adsorbent for blood purification, offering improved hemocompatibility.
Abstract

Keywords:
adsorption mechanismbiosafetycopper‐based metal–organic frameworkscreatinineheparin functionalization

More Related Videos

Surface Functionalization of Metal-Organic Frameworks for Improved Moisture Resistance08:12

Surface Functionalization of Metal-Organic Frameworks for Improved Moisture Resistance

Published on: September 5, 2018

16.6K
Synthesis and Characterization of Functionalized Metal-organic Frameworks11:27

Synthesis and Characterization of Functionalized Metal-organic Frameworks

Published on: September 5, 2014

49.1K

Related Concept Videos

Metallic Solids02:37

Metallic Solids

Metallic solids such as crystals of copper, aluminum, and iron are formed by metal atoms. The structure of metallic crystals is often described as a uniform distribution of atomic nuclei within a “sea” of delocalized electrons. The atoms within such a metallic solid are held together by a unique force known as metallic bonding that gives rise to many useful and varied bulk properties.
All metallic solids exhibit high thermal and electrical conductivity, metallic luster, and malleability....
20.6K
Bonding in Metals02:32

Bonding in Metals

Metallic bonds are formed between two metal atoms. A simplified model to describe metallic bonding has been developed by Paul Drüde called the “Electron Sea Model”. 
52.3K
Characteristics and Functions of Blood01:26

Characteristics and Functions of Blood

Blood is specialized connective tissue comprising about 8% of the body mass. It has a thick, liquid extracellular matrix that contains cells, dissolved proteins, and electrolytes, making it five times more viscous than water. Blood is warm, around 38°C, and has an alkaline pH ranging from 7.35 to 7.45.
The primary function of blood is to transport oxygen and carbon dioxide between tissues and the lungs. Oxygenated blood is bright red, while oxygen-depleted blood is darker. It also carries...
10.0K
Properties of Transition Metals02:58

Properties of Transition Metals

Transition metals are defined as those elements that have partially filled d orbitals. As shown in Figure 1, the d-block elements in groups 3–12 are transition elements. The f-block elements, also called inner transition metals (the lanthanides and actinides), also meet this criterion because the d orbital is partially occupied before the f orbitals.
29.7K
Analyte Adsorption and Distribution01:09

Analyte Adsorption and Distribution

In certain chromatographic separations, solutes transfer between the mobile phase and the stationary phase via sorption, which typically refers to the process of adsorption. For many chromatographic systems, the sorption process often depends on the polarity of the compounds—an expression of the overall dipole moment within the molecule. During the separation process, there is competition between the solute and solvent for adsorption to the stationary phase. Highly polar compounds and...
2.8K
Alkali Metals03:06

Alkali Metals

Group 1 elements are soft and shiny metallic solids. They are malleable, ductile, and good conductors of heat and electricity. The melting points of the alkali metals are unusually low for metals and decrease going down the group, while the density increases going down the group with the exception of potassium (Table 1).
Table 1: Properties of the alkali metals
24.5K