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Comparison of Serum Interleukin-6 of Parturients Undergoing Vaginal and Cesarean Delivery
Nitu Puthenveettil1, Aswathi Chenarath1, Divya Chandana1
1Department of Anesthesiology and Critical Care, Amrita Institute of Medical Sciences, Amrita Vishwa Vidyapeetham, Kochi, Kerala, India.
Background:
Parturients are concerned regarding the method of delivery. In this study, we are comparing the serum interleukin-6 (IL-6) levels and maternal and neonatal infection rate between parturients undergoing vaginal or cesarean delivery.
Methods:
This prospective study was conducted on 60 parturients undergoing normal delivery or elective cesarean delivery. Parturients were delivered as per institutional protocol. Maternal blood samples for assessment of serum IL-6 were collected within 10 min of delivery of the baby.
Results:
On comparing the serum IL-6, there was a significant difference with parturients undergoing normal delivery having higher values than cesarean delivery (73.35 ± 52.29 vs. 9.97 ± 26.49, P < 0.001). On comparing the incidence of maternal infection, cesarean section parturients had a higher incidence (10.0%) than vaginal delivery (3.3%), with P = 0.612, which is not statistically significant. When neonatal infection was compared, 6.7% in the normal delivery group and 16.7% in the cesarean group had infection, which was not statistically significant with P = 0.424.
Conclusion:
Our study demonstrates that vaginal delivery is associated with significantly higher serum IL-6 levels compared to cesarean delivery. While we did not find a statistically significant difference in the incidence of maternal or neonatal infections, the numerically higher rate of infection in the cesarean group was noted. The higher IL-6 levels in vaginal delivery may be beneficial for both parturients and newborns. Further research is warranted to fully elucidate the long-term significance of these observed differences and their impact on maternal and child health.
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