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Paralytic Ileus in a 45-Year-Old Female with Schizophrenia on Clozapine Therapy
Shivraj Prashant Patil1, Manasi Vinayak Harale, R Janani
1Department of General Medicine, Dr. D. Y. Patil Medical College and Research Centre, Mumbai, Maharashtra, India.
Abstract:
A 45-year-old woman who comes with complains of recurrent paradoxical loose stools and abdominal distension for 3 days. She had type II diabetes, schizophrenia, and a history of left below-knee amputation. While there was no indication of a mechanical blockage, imaging tests revealed paralytic ileus. A potentially fatal gastrointestinal side effect that is frequently associated with anticholinergic drugs, such as clozapine, is paralytic ileus. Full recovery was achieved with conservative treatment and a reduction in the dosage of clozapine. This instance highlights how important it is to identify and treat drug-induced gastrointestinal dysmotility as soon as possible.
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