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Proteomic Profiling of Non-Muscle Invasive Bladder Cancer Reveals Potential Biomarkers for Recurrence and Progression

Tiago Aparecido Silva1, Luciana Godoy Viana2, Valdemir Melechco Carvalho2

  • 1Department of Surgery, Division of Urology, Federal University of São Paulo, Rua Botucatu, 740─Vila Clementino, São Paulo 04023062, Brazil.

Journal of Proteome Research
|January 26, 2026
PubMed
Summary
This summary is machine-generated.

This study identified novel protein biomarkers in nonmuscle invasive bladder cancer (NMIBC) tissues. These proteins may aid in diagnosing, predicting recurrence, and treating NMIBC.

Keywords:
biomarkerbladder cancerbladder tissuenetworksnonmuscle invasive cancerprogression riskprotein interactionproteomicrecurrence riskurothelial carcinoma

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Area of Science:

  • Proteomics
  • Oncology
  • Biomarker Discovery

Background:

  • Nonmuscle invasive bladder cancer (NMIBC) presents significant challenges due to high recurrence and progression rates.
  • Identifying reliable biomarkers is crucial for improved patient management and treatment strategies.

Purpose of the Study:

  • To characterize proteomic differences between NMIBC tumor and matched control bladder tissues.
  • To identify potential protein biomarkers and elucidate underlying molecular mechanisms in NMIBC.

Main Methods:

  • Proteomic analysis using data-independent acquisition on 45 paired NMIBC tumor and control tissue samples.
  • Statistical comparison using paired Student's t-test, focusing on proteins detected in at least 50% of samples.

Main Results:

  • 188 differentially abundant proteins and 11 tumor-exclusive proteins were identified.
  • Specific proteins (CNDP2, CTSD, EPS8L2, KRT7) showed correlations with tumor recurrence, progression risk, and staging.
  • Protein interaction network analysis highlighted key proteins like AGR2, FLNA, TPM1, and CALD1.

Conclusions:

  • This research identified potential protein biomarkers and therapeutic targets for NMIBC.
  • Proteins associated with recurrence and staging require further validation for clinical application in NMIBC diagnosis and treatment.