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Stem cell therapies for pulmonary fibrosis: emerging hope through ongoing challenges

Hanyu Shi1, Ruihui Geng1, Hui Liu2

  • 1Department of Internal Medicine, Hospital of the First Mobile Corps of the Chinese People's Armed Police Force, Dingzhou, 073099, Hebei, China.

Stem Cell Research & Therapy
|January 26, 2026
PubMed

Insights

Stem cell therapy shows promise for pulmonary fibrosis (PF), a serious lung condition. A review of clinical trials up to 2024 assessed its potential as an effective treatment.

Area of Science:

  • Regenerative Medicine
  • Pulmonary Medicine
  • Clinical Research

Background:

  • Pulmonary fibrosis (PF) is a severe, progressive lung disease with limited treatment options.
  • Stem cell therapy is an emerging field with potential therapeutic applications for PF.
  • Identifying effective stem cell interventions is crucial for improving patient outcomes.

Purpose of the Study:

  • To systematically review registered stem cell clinical trials for pulmonary fibrosis.
  • To assess the landscape of ongoing and completed stem cell research for PF up to 2024.
  • To provide an overview of current stem cell trial interventions for this debilitating lung disease.

Main Methods:

  • Systematic retrospective review of clinical trials.
  • Searched multiple databases including Trialtrove for PF stem cell trials.
  • Included trials registered up to the end of 2024.

Main Results:

  • The review identified a growing number of stem cell clinical trials for PF.
  • Analysis of trial designs and reported outcomes is ongoing.
  • Preliminary data suggests various stem cell types and delivery methods are being investigated.

Conclusions:

  • Stem cell therapy is a rapidly developing area of research for pulmonary fibrosis.
  • Further analysis of trial data is needed to determine efficacy and safety.
  • This review highlights the increasing global effort to find novel treatments for PF using stem cells.
Keywords:
Clinical trialPulmonary fibrosisStem cell

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