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Utilizing Extracellular Vesicles for Delivering Therapies in Neurodegenerative Disorders.
Ashish Dilip Sutar1, Anuja Shashikant Kamble1, Nitin Chitranshi2
1Department of Pharmaceutics, National Institute of Pharmaceutical Education and Research (NIPER-Raebareli), Bijnor-Sisendi Road, Sarojini Nagar, Near CRPF Base Camp, Lucknow, UP, 226002, India.
Current Drug Delivery
|January 26, 2026
Summary
Extracellular vesicles (EVs) offer a promising solution for treating neurodegenerative diseases (NDs) by crossing the blood-brain barrier. These vesicles show potential in preclinical models for neuroprotection and reducing cognitive deficits.
Area of Science:
- Neuroscience
- Biotechnology
- Pharmacology
Background:
- Neurodegenerative diseases (NDs) present diagnostic and therapeutic challenges due to slow progression and the blood-brain barrier (BBB).
- Conventional therapies are often limited by the BBB, hindering effective drug delivery to the brain.
- Extracellular vesicles (EVs) are increasingly recognized for their therapeutic potential in neurological disorders.
Purpose of the Study:
- To review the applications of extracellular vesicles (EVs) as a drug delivery system for neurodegenerative diseases (NDs).
- To discuss the challenges and future directions for EV-based therapies in treating NDs.
- To explore the potential of EVs in overcoming the limitations of conventional treatments for brain disorders.
Main Methods:
- Literature review of preclinical and clinical studies on extracellular vesicles (EVs) for neurodegenerative diseases (NDs).
- Analysis of EV properties, including their ability to cross the blood-brain barrier (BBB) and their therapeutic mechanisms.
- Examination of current challenges and regulatory considerations for EV-based drug delivery.
Main Results:
- Extracellular vesicles (EVs) demonstrate significant potential in preclinical models for mitigating neuroinflammation, reducing neuronal damage, and improving cognitive deficits in neurodegenerative diseases (NDs).
- EVs possess inherent properties like low immunogenicity, high biocompatibility, and efficient delivery, enabling them to traverse the blood-brain barrier (BBB).
- EVs facilitate intercellular communication by transporting crucial biomolecules, contributing to neuroprotection and modulation of cellular functions.
Conclusions:
- Extracellular vesicles (EVs) represent a promising therapeutic strategy for neurodegenerative diseases (NDs), offering a way to overcome the blood-brain barrier (BBB).
- Further research and regulatory advancements are necessary to translate the therapeutic potential of EVs into clinical practice for brain disorders.
- EV-based therapies hold promise for improving treatment efficacy and patient outcomes in neurodegenerative conditions.
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