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Hellenic Postprandial Lipemia Study (HPLS): A Prospective Cohort Trial on the Effect of Statins on Postprandial

Genovefa D Kolovou1, Theodoros Katsikas2, Petros Kalogeropoulos1

  • 1Department of Cardiology, Cardiometabolic Center, Lipoprotein Apheresis and Lipid Disorders Clinic, Metropolitan Hospital, Athens, Greece.

Current Vascular Pharmacology
|January 27, 2026
PubMed

Insights

Nearly 30% of high-risk individuals exhibit postprandial hypertriglyceridemia, a risk factor for atherosclerotic cardiovascular disease (ASCVD). Statin therapy effectively normalized abnormal postprandial lipemia in most participants, reducing triglyceride levels.

Area of Science:

  • Cardiology
  • Lipid Metabolism
  • Preventive Medicine

Background:

  • Postprandial hypertriglyceridemia is linked to atherosclerotic cardiovascular disease (ASCVD).
  • The Hellenic Postprandial Lipemia Study (HPLS) is a large prospective trial investigating statin effects on postprandial lipemia.

Purpose of the Study:

  • To assess the prevalence of postprandial hypertriglyceridemia in high-risk ASCVD individuals.
  • To evaluate the efficacy of statin therapy in managing postprandial lipemia.

Main Methods:

  • 900 high/very high ASCVD risk individuals were enrolled.
  • Triglyceride levels (fasting and postprandial) were measured at baseline and after statin treatment.
  • Participants received statin therapy after baseline assessment.

Main Results:

  • 29.9% of participants showed abnormal postprandial triglyceride (pTG) response.
  • Statin treatment significantly reduced mean pTG levels from 188 mg/dL to 140 mg/dL.
  • Fasting glucose did not influence pTG response in statin-treated individuals.

Conclusions:

  • Postprandial hypertriglyceridemia affects nearly 30% of high-risk ASCVD individuals.
  • Statin therapy normalized abnormal postprandial lipemia in 75.6% of participants.
  • Statins effectively lowered pTG levels, even in those with normal fasting triglyceride levels.
Abstract

Keywords:
CV riskPostprandial lipemiaatherosclerotic cardiovascular diseasedyslipidemiahypertriglyceridemiaoral fat tolerance testresidual risk.statins

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