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Updated: Jan 28, 2026

Multi-exon Skipping Using Cocktail Antisense Oligonucleotides in the Canine X-linked Muscular Dystrophy
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MET Exon 14 Skipping Mutation in NSCLC: From Genomic Discovery to Biomarker-Guided Therapeutic Innovation

Xiang Huang1, Shimei Zhang2, Linjuan Wang3

  • 1Women and Children's Hospital, School of Public Health, Xiamen University, Xiamen, 361000, China.

Current Drug Targets
|January 27, 2026
PubMed
Abstract

Insights

The MET exon 14 skipping mutation drives non-small cell lung cancer (NSCLC) progression. MET inhibitors show high efficacy in clinical trials, offering a targeted therapy for NSCLC patients.

Area of Science:

  • Oncology
  • Molecular Biology
  • Genetics

Background:

  • Non-small cell lung cancer (NSCLC) is the most prevalent lung malignancy.
  • The MET exon 14 skipping mutation acts as a critical oncogenic driver in NSCLC.
  • This mutation presents a significant target for precision therapy in NSCLC management.

Purpose of the Study:

  • To review the role of the MET exon 14 skipping mutation in NSCLC.
  • To summarize recent therapeutic advancements for NSCLC patients with this mutation.
  • To evaluate the efficacy and challenges of MET inhibitors in NSCLC treatment.

Main Methods:

  • Systematic literature and clinical trial data search (2020-2025).
  • Analysis of detection methods including DNA-based NGS, RNA-based NGS, and RT-qPCR.
  • Review of preclinical models and clinical trial outcomes for MET inhibitors.

Main Results:

  • Preclinical data indicate MET exon 14 skipping mutations activate the RAS/MAPK pathway, promoting tumor growth.
  • Clinical trials demonstrate objective remission rates of 46-68% with first-line MET inhibitors in NSCLC.
  • MET inhibitors are recommended as a first-line treatment option by major guidelines.

Conclusions:

  • MET exon 14 skipping mutation is a validated therapeutic target in NSCLC.
  • MET inhibitors offer superior outcomes compared to chemotherapy and immunotherapy.
  • Addressing drug resistance and integrating multi-omics approaches are crucial for advancing precision medicine in NSCLC.
Keywords:
MET exon 14 skipping mutationdrug resistanceliquid biopsynon-small-cell lung cancerprecision medicinetargeted therapy

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