Future burden of MASLD in the United States: A state-level forecasting study, 2022-2050
Contact us if these videos are not relevant.
Contact us if these videos are not relevant.
View abstract on PubMed
Summary
This summary is machine-generated.Metabolic dysfunction-associated steatotic liver disease (MASLD) projections show a substantial future burden in the US, with significant costs and geographic disparities. Targeted public health strategies are crucial for addressing this growing epidemic.
Area Of Science
- Public Health
- Epidemiology
- Health Economics
Background
- Metabolic dysfunction-associated steatotic liver disease (MASLD) prevalence is rising globally.
- Quantifying the future subnational burden of MASLD is essential for effective public health planning.
- Current data lacks state-specific projections for MASLD's future impact.
Purpose Of The Study
- To project the future burden of MASLD at the state level in the United States through 2050.
- To estimate the associated direct healthcare costs of MASLD.
- To inform policy and resource allocation for targeted public health interventions.
Main Methods
- Developed a state-level forecasting model using Global Burden of Disease (GBD) 2021 data.
- Utilized time-series forecasting (ARIMA/ETS) for age- and sex-specific MASLD DALY rates (1990-2021).
- Applied projected rates to state population projections and calculated healthcare costs with probabilistic sensitivity analysis.
Main Results
- Projected total US MASLD burden of 5.5 million DALYs and over $2.3 trillion in healthcare costs by 2050.
- California, Texas, and Florida are projected to have the highest absolute MASLD burden.
- Higher DALY rates per capita are anticipated in Southern and Appalachian states.
Conclusions
- The future burden of MASLD in the US is substantial, increasing, and geographically uneven.
- State-level projections highlight the need for tailored regional public health strategies.
- Data supports informed state-level policy and resource allocation to combat the MASLD epidemic.
Contact us if these videos are not relevant.
Contact us if these videos are not relevant.
Related Concept Videos
Every measurement provides three kinds of information: the size or magnitude of the measurement (a number), a standard of comparison for the measurement (a unit), and an indication of the uncertainty of the measurement. While the number and unit are explicitly represented when a quantity is written, the uncertainty is an aspect of the errors in the measurement results.
The number in the measurement can be represented in different ways, including decimal form and scientific notation, which is...
The International System of Units or SI system, by international agreement, has fixed measurement units for seven fundamental properties: length, mass, time, temperature, electric current, amount of substance, and luminosity. These are called the SI base units.
Units of measurement derived from the mathematical combination of SI base units are called SI-derived units. For example, the ratio of the SI unit for distance (meter; m) and the SI unit for time (second; s) gives the SI-derived unit...
Biological organization is the classification of biological structures, ranging from atoms at the bottom of the hierarchy to the Earth's biosphere. Each level of the hierarchy represents an increase in complexity that builds upon the previous level.
Molecules Are Composed of Atoms, and Biomolecules Are Assembled from Molecules:
The most basic levels include atoms, molecules, and biomolecules. Atoms, the smallest unit of ordinary matter, are composed of a nucleus and electrons. Molecules...
A motor unit consists of two main components: a single efferent motor neuron (i.e., a neuron that carries impulses away from the central nervous system) and all of the muscle fibers it innervates. The motor neuron may innervate multiple muscle fibers, which are single cells, but only one motor neuron innervates a single muscle fiber.
Lower motor neurons are efferent neurons that control skeletal muscle, the most abundant type of muscle in the body. The cell bodies of lower motor neurons are...
The motor unit is a fundamental component of the neuromuscular system and plays a crucial role in coordinating muscle contractions. It consists of a somatic motor neuron, which connects and controls multiple skeletal muscle fibers, forming a single functional segment. The axon of the motor neuron branches out and establishes synaptic connections known as neuromuscular junctions with individual muscle fibers within the motor unit.
Motor units come in different sizes, with smaller units...
Mechanical engineering is one of the oldest branches of engineering. It deals with designing, analyzing, and manufacturing machines and mechanical systems. To ensure precise and accurate calculations, units of measurement are used. They provide a standard system for expressing and comparing physical quantities.
There are various well-known historical measurement systems, such as the Babylonian system, the Roman system, the Egyptian system, the Olympian system, the British system, and the Indus...