[Correlation between adenoid hypertrophy combined with secretory otitis media and laryngopharyngeal reflux in children]
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View abstract on PubMed
Summary
This summary is machine-generated.Laryngopharyngeal reflux (LPR) is a key factor in children with adenoid hypertrophy (AH) and secretory otitis media (SOM). Combining the Reflux Symptom Index (RSI) and Reflux Finding Score (RFS) offers a practical diagnostic tool for LPR in this patient group.
Area Of Science
- Pediatric Otolaryngology
- Gastroenterology
- Reflux Disease
Background
- Adenoid hypertrophy (AH) and secretory otitis media (SOM) are common in children.
- The role of laryngopharyngeal reflux (LPR) in the pathogenesis of AH complicated by SOM requires further investigation.
- Accurate diagnostic tools for LPR are needed in pediatric populations.
Purpose Of The Study
- To investigate the association between LPR and AH with SOM in children.
- To evaluate the diagnostic accuracy of the Reflux Symptom Index (RSI) and Reflux Finding Score (RFS) for LPR.
- To compare RSI and RFS against pepsin immunohistochemistry of adenoid tissue.
Main Methods
- Analysis of clinical data from 80 children undergoing surgery for AH.
- Pepsin immunohistochemistry staining of adenoid tissues to detect LPR.
- Comparison of reflux-related indices (RFS, RSI, favorable area ratio, H-SCORE) between children with and without SOM.
- Evaluation of the predictive accuracy of RSI and RFS using pepsin staining as the reference standard.
Main Results
- Significant differences in RFS and RSI scores were observed between children with and without SOM (P<0.01 and P=0.013, respectively).
- Pepsin immunohistochemistry revealed higher pepsin expression (favorable area ratio and H-SCORE) in children with SOM (P<0.01).
- The combined use of RSI and RFS demonstrated improved sensitivity and positive predictive value for detecting LPR compared to individual scores.
Conclusions
- LPR is implicated as a significant pathogenic factor in children with concurrent AH and SOM.
- The combined application of RSI and RFS serves as a convenient, office-based method for identifying LPR in pediatric patients with AH and SOM.
- Further research can explore therapeutic interventions targeting LPR in this population.
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