An electrochemical immunosensor based on MXene-Au and Au-Ce-COF to detect methyl parathion

A novel electrochemical immunosensor based on MXene-Au and Au-Ce-COF was constructed and applied for the ultra-sensitive detection of methyl parathion (PTM). The MXene-Au nanomaterials were obtained by acid etching the precursor to obtain layered MXene, and then generating gold nanoparticles (Au NPs) in situ on the MXene surface. A Au-Ce-COF was synthesized by first synthesizing a Ce-COF through simple stirring under nitrogen (N₂), and then Au NPs were generated by reducing HAuCl₄ (chloroauric acid); finally, the material was ultrasonically synthesized to form the final product. The materials were characterized by multiple techniques with their electrochemical properties evaluated via cyclic voltammetry (CV). Electrochemical test results indicate that the fabricated sensor demonstrates outstanding electrocatalytic performance for PTM detection. In addition, the constructed sensor shows an extended linear response range (0.00475-9.5 μg mL^-1), lower limit of detection (1.58 ng mL^-1), and promising application in practical assays.