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Structural and Functional Insights Into Lyn Kinase: From Immune Regulation to Therapeutic Targeting.

Alisha Khan1, Aaliya Taiyab2, Gulam Mustafa Hasan3

  • 1Department of Biotechnology, School of Chemical and Life Sciences, Jamia Hamdard, Hamdard Nagar, New Delhi, India.

Journal of Cellular Biochemistry
|January 27, 2026
PubMed
Summary

Lyn kinase regulates immune cell signaling and is implicated in various diseases. Targeting Lyn kinase with inhibitors or natural compounds shows therapeutic promise for cancers and other disorders.

Keywords:
Src family kinasesmetabolic regulationoncogenic signalingprotein structure‐function relationshipprotein–protein interactionsignal transduction

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Area of Science:

  • Biochemistry
  • Molecular Biology
  • Immunology

Background:

  • Lyn kinase, a Src family kinase, is crucial for immune cell signaling pathways.
  • Dysregulated Lyn kinase activity is linked to numerous diseases, including cancers and autoimmune disorders.

Purpose of the Study:

  • To comprehensively review Lyn kinase biology, its signaling roles, and pathological implications.
  • To explore therapeutic strategies targeting Lyn kinase for various diseases.

Main Methods:

  • Literature review of Lyn kinase structure, function, and disease association.
  • Analysis of therapeutic approaches including small-molecule inhibitors, antibodies, and natural compounds.

Main Results:

  • Lyn kinase overexpression drives tumor growth and treatment resistance in multiple cancers.
  • Emerging evidence connects Lyn kinase to neuroinflammation, synaptic dysfunction, and metabolic regulation.

Conclusions:

  • Lyn kinase is a significant drug target with broad therapeutic potential.
  • Small-molecule inhibitors, monoclonal antibodies, and natural compounds show promise for Lyn kinase-targeted therapies.