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Updated: Jan 28, 2026
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Measuring Frailty in HIV-infected Individuals. Identification of Frail Patients is the First Step to Amelioration and Reversal of Frailty
Published on: July 24, 2013
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A Positive Association Between Frailty and Overactive Bladder in United States Adults
Gaoxu Yu1, Wenfeng Lu2, Qingyun Wang2
1Department of Anesthesiology, Affiliated Xuancheng Hospital of Wannan Medical College, Xuancheng, Anhui Province, China.
Neurourology and Urodynamics
|January 27, 2026
Summary
Frailty is significantly linked to overactive bladder (OAB) in adults. This study found a robust association, highlighting the need for further investigation into the connection between frailty and OAB.
Area of Science:
- Gerontology
- Urology
- Public Health
Background:
- Frailty is a known risk factor for various chronic diseases.
- The relationship between frailty and overactive bladder (OAB) remains underexplored.
- Understanding this link is crucial for geriatric and urological health.
Purpose of the Study:
- To investigate the association between frailty and overactive bladder (OAB) in a large population.
- To explore potential dose-response relationships and effect modifications.
Main Methods:
- Analysis of 11,888 participants (aged ≥20 years) from the 2007-2018 NHANES.
- Frailty assessed using a 49-item deficit accumulation model (≥0.21 indicates frailty).
- OAB diagnosed via self-report (urgency incontinence, nocturia) and OAB Symptom Score (≥3), analyzed with multivariable logistic regression and restricted cubic splines (RCS).
Main Results:
- A significant positive association was found between frailty and OAB (OR=2.74, 95% CI: 2.39-3.13).
- RCS analysis confirmed a nonlinear dose-response relationship (p<0.001).
- The association was stronger in non-diabetic individuals and those with vigorous physical activity.
Conclusions:
- A robust association exists between frailty and OAB.
- Further research is needed to confirm this correlation and elucidate underlying mechanisms.
- Findings suggest frailty may be an important factor in OAB development and management.
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