Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Concept Videos

Field Effect Transistor01:29

Field Effect Transistor

1.2K
Field-effect transistors (FETs) are integral to electronic circuits and distinguished by their three-terminal setup: the gate, drain, and source. These transistors operate as unipolar devices, which utilize either electrons or holes as charge carriers, in contrast to bipolar transistors, which use both types of carriers. The primary function of the FET is to modulate the flow of these carriers from the source to the drain through a channel. The voltage difference between the gate and source...
1.2K
Bipolar Junction Transistor01:22

Bipolar Junction Transistor

1.5K
Bipolar Junction Transistors (BJTs) are essential elements in electronic circuits, playing a crucial role in the functionality of amplifiers, memories, and microprocessors. These transistors can be designed as NPN or PNP based on their doping patterns. They consist of three layers: the emitter, base, and collector. The configuration of these layers and their respective doping levels—with N-type or P-type impurities—define the transistor's type and its operational...
1.5K
Ligand-Gated Ion Channel Receptor: Gating Mechanism01:30

Ligand-Gated Ion Channel Receptor: Gating Mechanism

3.9K
Ligand-gated ion channels are transmembrane proteins that play a vital role in intercellular communication and functions of the nervous system. They allow the influx of ions across the membrane once the neurotransmitter binds, allowing the subsequent transmission of electrical excitation across the neurons. Other ligand-gated ion channels, like the γ-aminobutyric acid (GABA) receptor, permit anions like chloride into the cells on the binding of the GABA molecule. Their entry into the cell...
3.9K
Underflow Gates01:30

Underflow Gates

407
Underflow gates are vital for controlling water flow in irrigation canals. The three main types of underflow gates — vertical, radial, and drum gates — serve different purposes while ensuring effective flow management. Vertical gates move up and down, generating a free-flowing water jet; radial gates pivot to regulate the flow; and drum gates rotate for precise adjustments. The flow through these gates is influenced by downstream conditions, resulting in free or drowned outflow.Free and...
407
Non-gated Ion Channels01:24

Non-gated Ion Channels

8.2K
Ion channels are specialized proteins on the plasma membrane that allow charged ions to pass down their electrochemical gradient. Their main function is to maintain the membrane potential which is critical for cell viability. These channels are either gated or non-gated and can transport more than a thousand ions within milliseconds for the cellular event to occur.
Compared to the gated ion channels, the non-gated channels, also known as leakage or passive channels, have no gating mechanism....
8.2K
Mechanically-gated Ion Channels01:12

Mechanically-gated Ion Channels

7.7K
Mechanically-gated ion channels are proteins found in eukaryotic and prokaryotic cell membranes that open in response to mechanical stress. Tension, compression, swelling, and shear stress can alter the conformation of the protein, opening a transmembrane channel that allows the passage of ions for signal transmission. In eukaryotes, mechanically-gated channels are distributed in several regions like the neurons, lungs, skin, bladder, and heart, where they play critical roles in numerous...
7.7K

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

Genome evolution and transposable element expansion reveal host-associated genomic features in Cladosporium cucumerinum.

Communications biology·2026
Same author

Salvianic Acid A Regulates Ferroptosis by Activating the Nrf2-GPX4 Pathway Through EGFR to Protect Myocardial Ischemia-Reperfusion Injury.

Journal of inflammation research·2026
Same author

Icaritin plus TACE improves survival in advanced HCC with macrovascular invasion: a multicenter cohort study.

Frontiers in immunology·2026
Same author

Tuina inhibits ferroptosis and inflammatory response in nucleus pulposus of intervertebral disc degeneration rats.

Journal of orthopaedic surgery (Hong Kong)·2026
Same author

Correction: CCBE1 promotes GIST development through enhancing angiogenesis and mediating resistance to imatinib.

Scientific reports·2026
Same author

Template-Assisted Synthesis of Hierarchical Gas Sensing Materials: From Structural Design to Performance Optimization.

Chemistry (Weinheim an der Bergstrasse, Germany)·2026

Related Experiment Video

Updated: Jan 28, 2026

Development and Functionalization of Electrolyte-Gated Graphene Field-Effect Transistor for Biomarker Detection
07:51

Development and Functionalization of Electrolyte-Gated Graphene Field-Effect Transistor for Biomarker Detection

Published on: February 1, 2022

3.8K

Aptamer-Functionalized Microchannel-Gated Field-Effect Transistor Biosensor for In Vivo Detection of Dopamine.

Yulan Zeng1, Lin Tu2, Huabin Cai1

  • 1Ministry of Education Key Laboratory for Analytical Science of Food Safety and Biology, Fujian Provincial Key Laboratory of Analysis and Detection for Food Safety, College of Chemistry, Fuzhou University, Fuzhou, Fujian 350108, China.

Analytical Chemistry
|January 27, 2026
PubMed
Summary

This study presents a novel biosensor using a microchannel-gated junction field-effect transistor (JFET) for sensitive dopamine detection. The device achieves low detection limits and demonstrates potential for in vivo biomolecule analysis.

More Related Videos

Detecting Anastasis In Vivo by CaspaseTracker Biosensor
20:16

Detecting Anastasis In Vivo by CaspaseTracker Biosensor

Published on: February 1, 2018

9.7K
Preparation of Silicon Nanowire Field-effect Transistor for Chemical and Biosensing Applications
11:25

Preparation of Silicon Nanowire Field-effect Transistor for Chemical and Biosensing Applications

Published on: April 21, 2016

11.6K

Related Experiment Videos

Last Updated: Jan 28, 2026

Development and Functionalization of Electrolyte-Gated Graphene Field-Effect Transistor for Biomarker Detection
07:51

Development and Functionalization of Electrolyte-Gated Graphene Field-Effect Transistor for Biomarker Detection

Published on: February 1, 2022

3.8K
Detecting Anastasis In Vivo by CaspaseTracker Biosensor
20:16

Detecting Anastasis In Vivo by CaspaseTracker Biosensor

Published on: February 1, 2018

9.7K
Preparation of Silicon Nanowire Field-effect Transistor for Chemical and Biosensing Applications
11:25

Preparation of Silicon Nanowire Field-effect Transistor for Chemical and Biosensing Applications

Published on: April 21, 2016

11.6K

Area of Science:

  • Biomolecular Engineering
  • Sensor Technology
  • Analytical Chemistry

Background:

  • Field-effect transistors (FETs) are valuable in biosensing due to signal amplification.
  • Glass microchannels provide mechanical stability and surface modification for in vivo applications.

Purpose of the Study:

  • To develop a sensitive biosensor for dopamine detection using a microchannel-coupled junction FET (JFET).
  • To immobilize a dopamine aptamer within a microchannel to act as a recognition element.

Main Methods:

  • A microchannel was integrated with a JFET, with the microchannel serving as an extended gate.
  • Dopamine aptamers were immobilized on the microchannel's inner wall to capture dopamine.
  • The binding of dopamine altered the microchannel's resistance, modulating the JFET's gate voltage and current.

Main Results:

  • The biosensor demonstrated a linear response to dopamine concentration logarithmically from 1.00 nM to 10.0 μM.
  • A low detection limit of 0.15 nM (S/N = 3) was achieved for dopamine.
  • The biosensor showed high sensitivity and selectivity, successfully detecting dopamine in rat serum and brain tissue.

Conclusions:

  • The microchannel-gated JFET biosensor offers a sensitive and selective method for dopamine detection.
  • The device shows significant potential for real-time, trace biomolecule detection in vivo.