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Updated: Jan 28, 2026

Endoscopic Bilateral Nipple-sparing Mastectomy via a Single Axillary Incision with Immediate Pre-pectoral Implant-based Breast Reconstruction
Published on: May 17, 2024
Femtosecond Laser-Structured Polypropylene Mesh Implant for Enhanced Postoperative Recovery in Reconstructive Breast
Jian Gao1, Miao Yu1, Youdi Hu2
1Department of General Surgery, The First Affiliated Hospital of University of Science and Technology of China, Hefei, Anhui, China.
Abstract:
Polypropylene (PP) mesh implanting has emerged as a breast reconstruction approach to restore normal anatomical contours. However, developing biomedical PP mesh with enhanced anti-inflammatory properties, superior mechanical strength, and efficient manufacturing remains a significant challenge. In this study, we report a drug-loading PP mesh by incorporating triclosan into femtosecond (fs) laser-treated PP mesh scaffolds. The fs laser induced micro/nano structures significantly enhanced the drug-loading capacity and antibacterial efficacy of triclosan-modified PP mesh, as indicated by the area of inhibition rings (2.5-fold relative to the blank groups). In vivo breast reconstruction experiments using female Sprague-Dawley (SD) rats demonstrate accelerated scab formation and wound healing. Additionally, the Enzyme-linked immunosorbent assay (ELISA) test reveals high vascular density (11.43 µg/mL of CD31 and 0.32 µg/mL of CD163) and reduced proinflammatory cytokine levels (145 pg/mL of IL-6 and 33 pg/mL of TNF-a), further confirming the anti-inflammatory properties of the fs laser-treated triclosan-modified PP mesh. This study presents a novel approach to improving the clinical performance of PP meshes for biomedical applications.
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