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Updated: Jan 28, 2026
08:55
Hydroquinone Based Synthesis of Gold Nanorods
Published on: August 10, 2016
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PNVCL-Based Multifunctional Nanogels Loaded with Curcumin, 5-Fluorouracil, and Gold Nanorods: Their Performance in
Diana V Félix-Alcalá1, Mirian A González-Ayón1, Lizbeth A Manzanares-Guevara2
1Centro de Graduados e Investigación en Química, Tecnológico Nacional de México/Instituto Tecnológico de Tijuana, Apartado Postal 1166, Tijuana 22454, Mexico.
Gels (Basel, Switzerland)
|January 27, 2026
Summary
Researchers developed smart nanogels for colon cancer therapy, combining chemotherapy drugs and gold nanorods for targeted drug delivery and heat treatment. While showing promise, optimizing gold nanorod concentration and irradiation is key for enhanced chemo-photothermal synergy.
Area of Science:
- Biomedical Engineering
- Materials Science
- Nanotechnology
Background:
- Colon cancer therapy requires innovative drug delivery systems.
- Multifunctional nanocarriers offer potential for targeted and synergistic treatments.
Purpose of the Study:
- To develop and evaluate thermoresponsive nanogels for colon cancer therapy.
- To create a system combining chemotherapy, photothermal therapy, and targeted delivery.
Main Methods:
- Synthesized poly(N-vinylcaprolactam-co-N-vinylpyrrolidone) (P(NVCL-co-NVP)) nanogels with PEGMA shell and galactose (GAL) targeting ligand.
- Encapsulated curcumin (CUR), 5-fluorouracil (5-FU), and gold nanorods (GNRDs).
- Evaluated nanogel characteristics, drug release, biocompatibility, and in vitro efficacy on colon cancer cells.
Main Results:
- Nanogels exhibited thermoresponsive drug release and good biocompatibility.
- In vitro studies showed enhanced drug accumulation and photothermal ablation (at sufficient GNRD concentration).
- Chemo/photothermal combination efficacy was limited, suggesting a need for optimization.
Conclusions:
- P(NVCL-co-NVP):PEGMA:GAL nanogels are promising carriers for combined chemo-photothermal colon cancer therapy.
- Optimization of GNRD loading and irradiation dosage is crucial for maximizing therapeutic synergy.
- Further refinement could lead to more effective colon cancer treatment strategies.
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