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Development and Characterization of Clindamycin-Loaded Dextran Hydrogel for Controlled Drug Release and Pathogen
Iqra Jawad1, Asma Rehman1, Mariam Hamdan2
1Industrial Biotechnology Division, National Institute for Biotechnology and Genetic Engineering College, Pakistan Institute of Engineering and Applied Sciences (NIBGE-C, PIEAS), Faisalabad 38000, Pakistan.
Gels (Basel, Switzerland)
|January 27, 2026
Summary
This study developed a dextran hydrogel for controlled clindamycin delivery. The biocompatible hydrogel shows excellent swelling, stability, and pathogen-inhibitory properties, making it promising for drug delivery applications.
Area of Science:
- Biomaterials Science
- Polymer Chemistry
- Drug Delivery Systems
Background:
- Dextran is a natural, biocompatible, and biodegradable polymer ideal for hydrogel formulation.
- Hydrogels possess desirable properties for medical applications, including drug delivery and tissue engineering.
- Controlled drug delivery systems aim to improve therapeutic efficacy and patient compliance.
Purpose of the Study:
- To synthesize and characterize dextran hydrogel for clindamycin encapsulation.
- To evaluate the hydrogel's swelling behavior, pH and temperature dependence, and stability.
- To assess the drug loading capacity, in vitro drug release, and antimicrobial activity of clindamycin-loaded hydrogel.
Main Methods:
- Dextran hydrogel synthesis via a cost-effective method.
- Characterization of swelling ratio, pH/temperature dependence, and surface morphology (SEM).
- In vitro drug release studies and antimicrobial assays against Staphylococcus gallinarium and Bacillus subtilis.
Main Results:
- The hydrogel exhibited maximum swelling (73 ± 1%) in water at 25 °C within 120 min.
- Swelling behavior was pH- and temperature-dependent, indicating potential for targeted delivery.
- High drug loading (70 ± 2%), rapid in vitro release (65 ± 2%), and significant pathogen-inhibitory activity were observed.
Conclusions:
- Synthesized dextran hydrogel is a promising biomaterial for controlled clindamycin delivery.
- The hydrogel's properties support its use in advanced drug delivery systems.
- The material demonstrated efficacy against specific bacterial pathogens.
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