Related Experiment Video

Updated: Jan 28, 2026

Acupoint Needle-Embedding Combined with Ironing Therapy for Postoperative Pain After Anal Surgery
05:39

Acupoint Needle-Embedding Combined with Ironing Therapy for Postoperative Pain After Anal Surgery

Published on: June 23, 2023

2.1K

Prophylactic Antibiotic Therapy in Cleft Surgery-A Scoping Review

Margareta Budner1,2, Marcelina Podleśna2,3, Aleksandra Domańska4

  • 1Department of Jaw Orthopedics, Medical University of Lublin, 20-059 Lublin, Poland.

Dentistry Journal
|January 27, 2026
PubMed

Insights

Prophylactic antibiotic use in cleft lip and palate surgery shows wide variation. Short-course antibiotic strategies appear effective, highlighting the need for resistance-conscious guidelines and further research.

Area of Science:

  • Craniofacial surgery
  • Infectious disease
  • Pharmacology

Background:

  • Cleft lip and/or palate surgeries are clean-contaminated procedures susceptible to surgical site infections and palatal fistulas.
  • Current perioperative antibiotic use lacks standardized, evidence-based recommendations.
  • Rising antimicrobial resistance necessitates rational antibiotic prescribing in surgical settings.

Purpose of the Study:

  • To systematically map existing evidence on prophylactic antibiotic therapy in cleft surgery.
  • To identify related perioperative measures influencing outcomes.
  • To inform the development of standardized, resistance-conscious guidelines.

Main Methods:

  • A systematic scoping review following the Arksey and O'Malley framework, adhering to PRISMA 2020 guidelines.
  • Searched PubMed, Mendeley, and Google Scholar (Jan 2015-Feb 2025) for relevant English-language studies.
  • Data extraction by six reviewers focused on study characteristics, antibiotic regimens, and outcomes.

Main Results:

  • Forty studies met inclusion criteria, revealing significant variation in antibiotic choice, timing, and duration.
  • Single-dose perioperative prophylaxis demonstrated non-inferiority to prolonged courses in some cases.
  • Oral microbiota analysis indicated colonization by resistant pathogens in cleft patients.

Conclusions:

  • Evidence supports individualized, short-course perioperative antibiotic strategies over routine prolonged therapy.
  • Further high-quality randomized controlled trials and microbiological studies are essential.
  • Development of standardized, antimicrobial resistance-aware guidelines is needed for cleft surgery.

Keywords:
antibiotic prophylaxiscleft lipcleft palatedrug resistancemicrobialoral hygieneperioperative caretherapeutics

More Related Videos

Antibiotic Dereplication Using the Antibiotic Resistance Platform10:49

Antibiotic Dereplication Using the Antibiotic Resistance Platform

Published on: October 17, 2019

11.6K
Using SCOPE to Identify Potential Regulatory Motifs in Coregulated Genes07:55

Using SCOPE to Identify Potential Regulatory Motifs in Coregulated Genes

Published on: May 31, 2011

10.7K

Related Concept Videos

The Scope of Physics01:17

The Scope of Physics

Physics is concerned with the interactions of energy, matter, space, and time, in order to discover the underlying mechanisms that underpin all phenomena. The word "physics" comes from the Greek word "phúsis", which means nature. Physics seeks to comprehend the natural world around us at its most fundamental level. It emphasizes the use of quantitative laws to do this, which could be valuable in other fields that want to push the performance boundaries of present...
52.8K
Antibiotic Selection00:57

Antibiotic Selection

Overview
59.9K
Review and Preview01:10

Review and Preview

In statistics, several tools are used to interpret the data. Measures of central tendency represent the characteristics of the data, such as mean, median, and mode. Additionally, measures of variance like standard deviation and range are used to find the spread of data from the mean. Relative standing measures the distance between data locations. Commonly used measures of relative standings are percentile, z score, and quartiles.
Percentiles are a type of fractile that partition data into...
8.4K
Review and Preview01:13

Review and Preview

Data are individual items of information obtained from a population or sample. Data may be classified as qualitative (categorical), quantitative continuous, or quantitative discrete. Because it is not practical to measure the entire population in a study, researchers use samples to represent the population. A random sample is a representative group from the population chosen by using a method that gives each individual in the population an equal chance of being included in the sample. Random...
11.1K
Development of Antibiotic Resistance01:30

Development of Antibiotic Resistance

Antibiotic resistance is a major public health concern that arises when bacteria evolve mechanisms to withstand the effects of antibiotic treatments. This resistance can be intrinsic, acquired through genetic mutations, or transferred between bacteria via horizontal gene transfer. The development of antibiotic resistance poses significant challenges in treating bacterial infections and necessitates ongoing research to develop new therapeutic strategies.Intrinsic resistance occurs when bacterial...
1.5K
Gene Therapy00:59

Gene Therapy

Gene therapy is a technique where a gene is inserted into a person’s cells to prevent or treat a serious disease. The added gene may be a healthy version of the gene that is mutated in the patient, or it could be a different gene that inactivates or compensates for the patient’s disease-causing gene. For example, in patients with severe combined immunodeficiency (SCID) due to a mutation in the gene for the enzyme adenosine deaminase, a functioning version of the gene can be...
27.6K