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Updated: Jan 28, 2026

Ultrasensitive Detection of Biomarkers by Using a Molecular Imprinting Based Capacitive Biosensor
Published on: February 16, 2018
Electrochemical Detection of Cancer Biomarkers: From Molecular Sensing to Clinical Translation
Ahmed Nadeem-Tariq1, John Russell Rafanan1, Nicole Kang1
1Kirk Kerkorian School of Medicine, University of Nevada Las Vegas, 625 Shadow Lane, Las Vegas, NV 89106, USA.
Abstract:
Early cancer detection is crucial for improving survival rates and treatment outcomes. Electrochemical biosensors have emerged as powerful tools for early cancer detection due to their high sensitivity, specificity, and rapid detection capabilities. This review explores recent advancements (2015-2025) in electrochemical biosensors for cancer biomarker detection, their working principles, novel nanomaterial-based enhancements, challenges, and prospects for clinical applications. Specifically, we highlight the electrochemical detection of protein biomarkers (e.g., CEA, PSA, CRP), nucleic acid markers (ctDNA, miRNA, methylation patterns), and metabolic indicators, emphasizing their clinical relevance in early diagnosis and monitoring. Unlike previous reviews which focus on either biomarker classes or sensor platforms, this review uniquely integrates both factors. This review provides a novel perspective on how next-generation electrochemical biosensors can bridge the gap between laboratory development and real-world cancer diagnostics.
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