Wearable Sensing Systems for Multi-Modal Body Fluid Monitoring: Sensing-Combination Strategy, Platform-Integration...

Wearable multi-modal body fluid monitoring enables continuous, non-invasive, and context-aware assessment of human physiology. By integrating biochemical and physical information across multiple modalities, wearable systems overcome the limitations of single-marker sensing and provide a more holistic view of dynamic health states. This review offers a system-level overview of recent advances in multi-modal body fluid monitoring, structured into three hierarchical dimensions. We first examine sensing-combination strategies such as multi-marker analysis within single fluids, coupling biochemical signals with bioelectrical, mechanical, or thermal parameters, and emerging multi-fluid acquisition to improve analytical accuracy and physiological relevance. Next, we discuss platform-integration mechanisms based on biochemical, physical, and hybrid sensing principles, along with monolithic and modular architectures enabled by flexible electronics, microfluidics, microneedles, and smart textiles. Finally, the data-processing patterns are analyzed, involving cross-modal calibration, machine learning inference, and multi-level data fusion to enhance data reliability and support personalized and predictive healthcare. Beyond summarizing technical advances, this review establishes a comprehensive framework that moves beyond isolated signal acquisition or simple metric aggregation toward holistic physiological interpretation. It guides the development of next-generation wearable multi-modal body fluid monitoring systems that overcome the challenges of high integration, miniaturization, and personalized medical applications.