SOGUG Multidisciplinary Expert Panel Consensus on Updated Diagnosis and Characterization of Prostate Cancer Patients.

Area of Science:

• Oncology
• Genitourinary Cancer Research
• Medical Imaging

Background:

• Prostate cancer (PCa) management requires a comprehensive approach integrating various specialties.
• Current screening methods have limitations in detecting clinically significant PCa.
• Advances in imaging and molecular diagnostics offer new avenues for PCa assessment.

Purpose of the Study:

• To review and summarize current aspects of PCa screening, diagnosis, imaging, risk stratification, and molecular characterization.
• To emphasize the importance of a multidisciplinary team (MDT) approach in PCa care.
• To discuss the role of next-generation imaging (NGI) and genomic testing in PCa management.

Main Methods:

• Expert consensus and review of current literature on prostate cancer.
• Discussion of findings within the ENFOCA2 project by the Spanish Oncology Genitourinary Group (SOGUG).
• Evaluation of next-generation imaging (NGI) techniques, including PSMA PET/CT and multiparametric MRI (mpMRI).

Main Results:

• A multidisciplinary team (MDT) approach is essential for evidence-based, personalized PCa care.
• Population-based, risk-stratified screening is needed to improve detection of clinically significant PCa.
• Next-generation imaging (NGI) like PSMA PET/CT shows high sensitivity; mpMRI needs improvement for staging, potentially aided by molecular probes.
• Germline testing for specific genes (e.g., BRCA1/2, ATM) and genomic classifiers are vital for personalized treatment decisions.

Conclusions:

• Integrated, multidisciplinary care improves outcomes for prostate cancer patients.
• Risk-stratified screening and advanced diagnostics (NGI, genomic testing) are key to optimizing PCa detection and treatment.
• Adapting international guidelines for germline testing and utilizing genomic classifiers enhance personalized medicine in PCa.