Jove
Visualize
Contact Us

Related Concept Videos

Chronic Kidney Disease II: Clinical Manifestations01:24

Chronic Kidney Disease II: Clinical Manifestations

613
Chronic Kidney Disease (CKD) progressively impairs multiple body systems due to the accumulation of uremic toxins, which disrupt cellular functions across various organs.Neurologic symptomsNeurologic symptoms often arise early in CKD, as uremic toxin buildup drives changes in cognitive and motor functions. Patients frequently experience fatigue, headache, confusion, difficulty concentrating, and, in severe cases, seizures. Peripheral neuropathy commonly manifests as burning sensations in the...
613
The Extracellular Matrix01:42

The Extracellular Matrix

88.8K
Overview
88.8K
The Extracellular Matrix01:29

The Extracellular Matrix

12.1K
Overview
In order to maintain tissue organization, many animal cells are surrounded by structural molecules that make up the extracellular matrix (ECM). Together, the molecules in the ECM maintain the structural integrity of tissue as well as the remarkable specific properties of certain tissues.
Composition of the Extracellular Matrix
The extracellular matrix (ECM) is commonly composed of ground substance, a gel-like fluid, fibrous components, and many structurally and functionally diverse...
12.1K
Nucleic Acids02:43

Nucleic Acids

50.1K
Nucleic acids are the most important macromolecules for the continuity of life. They carry the cell's genetic blueprint and carry instructions for its functioning.
DNA and RNA
The two main types of nucleic acids are deoxyribonucleic acid (DNA) and ribonucleic acid (RNA). DNA is the genetic material in all living organisms, ranging from single-celled bacteria to multicellular mammals. It is in the nucleus of eukaryotes and in the organelles, chloroplasts, and mitochondria. In prokaryotes,...
50.1K
What is an Experiment?01:12

What is an Experiment?

17.7K
An experiment is a planned activity carried out under controlled conditions. The purpose of an experiment is to investigate the relationship between two variables. When one variable causes change in another, we call the first variable the explanatory or independent variable. The affected variable is called the response or dependent variable. In a randomized experiment, the researcher manipulates values of the explanatory variable and measures the resulting changes in the response variable. The...
17.7K
The Citric Acid Cycle02:36

The Citric Acid Cycle

161.9K
The citric acid cycle, also known as the Krebs cycle or TCA cycle, consists of several energy-generating reactions that yield one ATP molecule, three NADH molecules, one FADH2 molecule, and two CO2 molecules.
161.9K

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

Surgical Management of Tracheostomy in Patients with Severe Burns and Cervical Involvement: Impact on Cervical Wound-Healing Disturbance.

European burn journal·2026
Same author

Effects of primary admission vs. secondary transfer to burn centers on mortality: An analysis of the German Burn Registry.

Burns : journal of the International Society for Burn Injuries·2026
Same author

Application of Integrative Medicine in Plastic Surgery: A Real-World Data Study.

Medicina (Kaunas, Lithuania)·2025
Same author

Systemic Effects of Enzymatic Necrosectomy in Minor Burn Wounds Using NexoBrid<sup>®</sup>.

Journal of personalized medicine·2025
Same author

Can Pure Silk Compete with the Established Mepilex Ag<sup>®</sup> in the Treatment of Superficial Partial Thickness Burn Wounds? A Prospective Intraindividual Study.

European burn journal·2025
Same author

Epidemiological Characteristics and Prognostic Scoring in Toxic Epidermal Necrolysis and Stevens-Johnson Syndrome: Insights from a 17-Year Burn Center Experience.

Medicina (Kaunas, Lithuania)·2025
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Experiment Video

Updated: Jan 28, 2026

Murine Model of Wound Healing
05:39

Murine Model of Wound Healing

Published on: May 28, 2013

67.4K

Bioresorbable Polylactic Acid Matrix for Chronic Non-Healing Wounds: First Clinical Experience in Europe.

Ioannis-Fivos Megas1,2, Paul Christian Fuchs3,4, Florian Pinterits1

  • 1Department of Orthopaedic and Trauma Surgery, Center of Plastic Surgery, Hand Surgery and Microsurgery, Evangelisches Waldkrankenhaus Spandau, Stadtrandstraße 555, 13589 Berlin, Germany.

Journal of Personalized Medicine
|January 27, 2026
PubMed
Summary

Bioresorbable polylactic acid (PLA) matrices show significant promise for chronic wound healing. A study found a PLA matrix achieved 93.8% closure in complex wounds, highlighting its clinical effectiveness.

Keywords:
chronic woundspolylactic acidvenous leg ulcerwound closure matrixwound healing

More Related Videos

Scratch Migration Assay and Dorsal Skinfold Chamber for In Vitro and In Vivo Analysis of Wound Healing
09:34

Scratch Migration Assay and Dorsal Skinfold Chamber for In Vitro and In Vivo Analysis of Wound Healing

Published on: September 26, 2019

14.2K
Mongolian Gerbils as an Animal Model of Wound Healing
07:54

Mongolian Gerbils as an Animal Model of Wound Healing

Published on: January 6, 2023

2.4K

Related Experiment Videos

Last Updated: Jan 28, 2026

Murine Model of Wound Healing
05:39

Murine Model of Wound Healing

Published on: May 28, 2013

67.4K
Scratch Migration Assay and Dorsal Skinfold Chamber for In Vitro and In Vivo Analysis of Wound Healing
09:34

Scratch Migration Assay and Dorsal Skinfold Chamber for In Vitro and In Vivo Analysis of Wound Healing

Published on: September 26, 2019

14.2K
Mongolian Gerbils as an Animal Model of Wound Healing
07:54

Mongolian Gerbils as an Animal Model of Wound Healing

Published on: January 6, 2023

2.4K

Area of Science:

  • Biomaterials Science
  • Regenerative Medicine
  • Wound Care

Background:

  • Bioresorbable polylactic acid (PLA) matrices offer biocompatibility and tissue integration for wound healing.
  • PLA matrices may influence immune responses, aiding in tissue repair processes.

Purpose of the Study:

  • To evaluate the real-world clinical performance of a polylactic acid (PLA) matrix for chronic wound treatment.
  • To assess the efficacy of PLA matrices in a single-center, retrospective study setting.

Main Methods:

  • Retrospective analysis of 14 patients with 16 chronic wounds treated with PLA matrices.
  • Surgical debridement followed by PLA matrix application, with mean reapplication interval of 14 days.
  • Descriptive statistical analysis of anonymized patient data.

Main Results:

  • Complete wound closure achieved in 15 of 16 cases (93.8%) within a mean of 72.9 days.
  • Average patient age was 76.1 years; common causes included ischemia and trauma.
  • Mean hospitalization duration was 24.8 days; no skin grafting was required.

Conclusions:

  • The polylactic acid matrix demonstrated high short-term efficacy for chronic wound closure.
  • Effective treatment was observed in a diverse patient group without the need for skin grafts.
  • Further prospective studies are recommended for long-term follow-up and validation.