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Related Experiment Video

Updated: Jan 28, 2026

A Pediatric Concussion Model in Mice: Closed Head Injury with Long-Term Disorders (CHILD)

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Lipidomic Signatures in Pediatric Metabolic Disorders.

Monica Narvaez-Rivas¹, Kenneth D R Setchell^1,2

¹Division of Pathology & Laboratory Medicine, Cincinnati Children's Hospital Medical Center, Cincinnati, OH 45229, USA.

|January 27, 2026

Summary

Lipidomics advances pediatric precision medicine by identifying disease-specific lipid signatures in metabolic disorders. This technology aids early diagnosis, risk stratification, and targeted therapies for conditions like pediatric obesity and MASLD.

Keywords:

children lipidomics metabolic disorder

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Last Updated: Jan 28, 2026

A Pediatric Concussion Model in Mice: Closed Head Injury with Long-Term Disorders (CHILD)

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Lipidomics and Transcriptomics in Neurological Diseases

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Published on: March 18, 2022

Area of Science:

Biochemistry
Pediatric Medicine
Metabolomics

Background:

Lipids are vital biomolecules for cellular functions.
Dysregulation of lipid metabolism (dyslipidemia) is central to pediatric metabolic disorders.
Conventional assays have limitations in detecting subtle lipid changes.

Purpose of the Study:

To highlight the role of advanced lipidomics in pediatric research.
To explore lipidomics' potential in understanding and managing pediatric metabolic diseases.
To showcase lipidomics as a tool for precision medicine in pediatrics.

Main Methods:

High-resolution mass spectrometry-based lipidomics.
Profiling of over one-thousand lipid species.
Discovery of disease-specific lipid signatures.

Main Results:

Lipidomics enables detection of previously undetectable lipid signatures.
Identified lipid signatures are associated with various pediatric conditions.
Advanced lipidomic approaches improve characterization of rare metabolic disorders.

Conclusions:

Lipidomics is crucial for advancing pediatric precision medicine.
It offers new avenues for early diagnosis and risk stratification.
Lipidomics supports targeted therapeutic strategies for pediatric metabolic diseases.