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Updated: Jan 28, 2026

Biological Compatibility Profile on Biomaterials for Bone Regeneration
Published on: November 16, 2018
Advanced Biomaterials for Craniofacial Tissue Regeneration: From Fundamental Mechanism to Translational
Żaneta Anna Mierzejewska1, Valentina Veselinović2, Nataša Trtić2
1Institute of Biomedical Engineering, Faculty of Mechanical Department, Bialystok University of Technology, Wiejska 45C, 15-351 Bialystok, Poland.
Abstract:
Recent advances in biomaterials, immunomodulation, stem cell therapy, and biofabrication are reshaping maxillofacial surgery, shifting reconstruction paradigms toward biologically integrated and patient-specific tissue regeneration. This review provides a comprehensive synthesis of current and emerging strategies for bone and soft-tissue regeneration in the craniofacial region, with particular emphasis on bioactive ceramics, biodegradable polymers, hybrid composites, and stimuli-responsive smart materials. We further examine translational technologies such as extracellular vesicles, decellularized extracellular matrices, organoids, and 3D bioprinting, highlighting key challenges such as bioink standardization, perfusion limitations, and regulatory classification. Maxillofacial surgery is positioned for a paradigm shift toward personalized, biologically active, and clinically scalable regenerative solutions.
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