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Related Concept Videos

Structural Joints: Fibrous Joints01:03

Structural Joints: Fibrous Joints

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Fibrous joints are a type of joint where the bones are connected by fibrous connective tissue. These joints provide stability and minimal to no movement between the articulating bones. There are three types of fibrous joints.
Suture
All the bones of the skull, except for the mandible, are joined to each other by a fibrous joint called a suture. The fibrous connective tissue found at a suture strongly unites the adjacent skull bones and thus helps to protect the brain and form the face. In...
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Assessing Body Temperature - Tympanic membrane01:14

Assessing Body Temperature - Tympanic membrane

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Assessing tympanic membrane temperature involves using a tympanic membrane thermometer (TMT). Here is a step-by-step guide:
Step 1: Begin by practicing good hand hygiene to prevent the transmission of microorganisms.
Step 2: Turn on the thermometer and wait until the ready sign appears on the screen to ensure accurate measurement.
Step 3: Slide the probe cover in place to prevent cross-contamination.
Step 4: Instruct the patient to tilt their head to the side for comfort and check for cerumen...
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Globular and Fibrous Proteins02:21

Globular and Fibrous Proteins

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Many proteins can be classified into two distinct subtypes - globular or fibrous. These two types differ in their shapes and solubilities.
Globular proteins are also known as spheroproteins and typically are approximately round in shape. They contain a mix of amino acid types and contain differing sequences in their primary structures. Globular proteins have many different functions, such as enzymes, cellular messengers, and molecular transporters. These roles often require the proteins to be...
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Structural Protein Function01:56

Structural Protein Function

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Structural proteins are a category of proteins responsible for functions ranging from cell shape and movement to providing support to major structures such as bones, cartilage, hair, and muscles. This group includes proteins such as collagen, actin, myosin, and keratin.
Collagen, the most abundant protein in mammals, is found throughout the body. In connective tissue, such as skin, ligaments, and tendons, it provides tensile strength and elasticity.  In bones and teeth, it mineralizes to...
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Fruit Development, Structure, and Function01:58

Fruit Development, Structure, and Function

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Fruits form from a mature flower ovary. As seeds develop from the ovules contained within, the ovary wall undergoes a series of complex changes to form fruit. In some fruits, such as soybeans, the ovary wall dries; in other fruits, such as grapes, it remains fleshy. In some cases, organs other than the ovary contribute to fruit formation; such fruits are called accessory fruits.
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Mismatch Repair01:36

Mismatch Repair

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Overview
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Related Experiment Video

Updated: Jan 28, 2026

Electrospinning Fibrous Polymer Scaffolds for Tissue Engineering and Cell Culture
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Fibrous Biomaterial Scaffold for Tympanic Membrane Repair: Microarchitectural Engineering and Structure Function

Lea Jiang1, Chokri Cherif1, Michael Wöltje1

  • 1Institute of Textile Machinery and High Performance Material Technology, TUD Dresden University of Technology, 01069 Dresden, Germany.

Journal of Functional Biomaterials
|January 27, 2026
PubMed
Summary
This summary is machine-generated.

Fiber-based scaffolds offer a promising alternative for tympanic membrane (TM) repair, potentially overcoming limitations of current grafts. These advanced materials can be engineered to mimic native TM structure and function for improved hearing restoration.

Keywords:
additive manufacturingbiomaterialselectrospinningfibrous biomaterial scaffoldshearing lossmicroarchitectureotologyscaffold designtympanic membranetympanic membrane perforation

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Core/shell Printing Scaffolds For Tissue Engineering Of Tubular Structures
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Area of Science:

  • Biomaterials Engineering
  • Regenerative Medicine
  • Otolaryngology

Background:

  • Tympanic membrane (TM) perforations are common and can cause hearing loss if tissue regeneration is inadequate.
  • Autologous grafts, the current standard, have limitations including harvesting needs and suboptimal structural replication.
  • Native TM structure is complex, and current grafts often fail to restore optimal sound transmission.

Purpose of the Study:

  • To review contemporary fabrication methods for fiber-based scaffolds for TM repair.
  • To discuss evaluation procedures for these scaffolds and their impact on performance.
  • To explore the potential of fiber-based scaffolds as alternatives to autologous grafts.

Main Methods:

  • Review of electrospinning, additive manufacturing, melt electrowriting, and hybrid fabrication strategies.
  • Discussion of mechanical testing, microstructural imaging, and in vitro biocompatibility assays for scaffold evaluation.
  • Analysis of how scaffold microarchitecture influences mechanical behavior and cellular interactions.

Main Results:

  • Fiber-based scaffolds allow precise control over fiber orientation, porosity, and microarchitecture.
  • Biocompatible polymers like silk fibroin and PLA can be tailored for specific mechanical and degradation properties.
  • Evaluation methods confirm the potential of scaffolds to mimic native TM structure and function.

Conclusions:

  • Fiber-based scaffolds present a tunable and promising alternative for TM reconstruction.
  • Advanced fabrication and evaluation techniques are crucial for developing effective TM repair constructs.
  • These engineered scaffolds may facilitate the clinical translation of improved TM repair strategies.