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Nuclear magnetic resonance (NMR) spectroscopy is a very valuable analytical technique for researchers. It has been used for more than 50 years as an analytical tool. F. Bloch and E. Purcell formulated NMR in 1946 and won the 1952 Nobel Prize in Physics  for their work. Biological macromolecules such as proteins, nucleic acids, lipids, and organic molecules including pharmaceutical compounds, can be studied using this versatile tool that exploits the magnetic properties of certain nuclei.
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Related Experiment Video

Updated: Jan 28, 2026

An Integrated System to Remotely Trigger Intracellular Signal Transduction by Upconversion Nanoparticle-mediated Kinase Photoactivation
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Preparation Method of Upconversion Nanoparticles and Its Biological Application.

Liang Li1, Ming Li1

  • 1School of Medicine and Health, Yancheng Polytechnic College, Yancheng 224005, China.

Nanomaterials (Basel, Switzerland)
|January 27, 2026
PubMed
Summary

Upconversion nanoparticles (UCNPs) offer unique properties for advanced biomedical applications like deep-tissue imaging and targeted drug delivery. Their integration into intelligent therapeutic systems promises personalized medicine, though challenges in production and safety remain.

Keywords:
biological applicationsynthesis methodupconversion nanoparticles

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Area of Science:

  • Nanotechnology
  • Biomedical Engineering
  • Materials Science

Background:

  • Next-generation therapeutic devices require intelligent, integrated systems consolidating multiple functions.
  • Upconversion nanoparticles (UCNPs) possess unique physicochemical properties enabling multifunctional characteristics.

Purpose of the Study:

  • To review recent advances in the design and functionalization of UCNPs for biomedical applications.
  • To elucidate the role of UCNPs in developing integrated diagnostic and therapeutic platforms.
  • To explore the potential of UCNPs in intelligent responsive treatment systems and personalized medicine.

Main Methods:

  • Systematic review of literature on UCNP design and functionalization.
  • Analysis of UCNP properties including near-infrared excitation, deep-tissue penetration, low autofluorescence, and tunable multicolor emission.
  • Evaluation of UCNP applications in deep-tissue imaging, targeted drug delivery, and photodynamic therapy.

Main Results:

  • Refined preparation methods unlock novel UCNP functionalities for biomedical use.
  • UCNPs demonstrate substantial potential in deep-tissue imaging, targeted drug delivery, and photodynamic therapy.
  • UCNPs facilitate the development of integrated diagnostic and therapeutic platforms.

Conclusions:

  • UCNPs are key components for intelligent, responsive therapeutic systems and personalized medicine.
  • Addressing challenges in large-scale production, biosafety, and in vivo mechanisms is crucial for clinical translation.
  • Future interdisciplinary integration will enhance UCNP-based medical innovations.