Related Experiment Video
Updated: Jan 28, 2026
08:23
Real-time Breath Analysis by Using Secondary Nanoelectrospray Ionization Coupled to High Resolution Mass Spectrometry
Published on: March 9, 2018
9.3K
Real-Time and High-Resolution NIR-II-L Imaging of Netrin-1-Mediated Neurovascular Coupling Driven by Dose-Dependent
Yicong Wang1,2,3, Zi-Han Chen4, Jiajia Li1,2,3
1Department of Integrative Medicine and Neurobiology, School of Basic Medical Sciences, Shanghai Medical College, Brain Science Collaborative Innovation Center, State Key Laboratory of Medical Neurobiology, Fudan University, Shanghai, China.
Advanced Science (Weinheim, Baden-Wurttemberg, Germany)
|January 27, 2026
Summary
Electroacupuncture (EA) improves ovarian function by restoring neurovascular coupling, visualized using novel nanocrystals. This neuromodulation technique offers a new therapeutic strategy for conditions like polycystic ovary syndrome.
Area of Science:
- Biomedical Engineering
- Neuroscience
- Reproductive Biology
Background:
- Disrupted ovarian neurovascular coupling is linked to polycystic ovary syndrome.
- Electroacupuncture (EA) shows potential for improving ovarian function.
- Current methods lack real-time visualization of EA's neurovascular effects.
Purpose of the Study:
- To elucidate the mechanisms of EA-induced neurovascular changes in the ovary.
- To develop a real-time in vivo visualization strategy for ovarian neurovascular dynamics.
- To investigate the role of Netrin-1 in EA's therapeutic effects.
Main Methods:
- Utilized core-shell lanthanide nanocrystals for deep-tissue imaging in the NIR-II-L window.
- Performed real-time, high-resolution visualization of ovarian blood vessels during EA.
- Analyzed immediate (iEA) and cumulative (cEA) EA effects on vasodilation and perfusion.
- Validated the involvement of Netrin-1.
Main Results:
- EA induced transient ovarian vasodilation (iEA) and sustained improvements in perfusion and follicular development (cEA).
- EA strengthened sympathetic-vascular coupling.
- Netrin-1 was identified as a key mediator of EA's effects on ovarian neurovascular remodeling.
Conclusions:
- EA modulates ovarian function through specific neurovascular mechanisms.
- Lanthanide nanocrystals provide a powerful tool for visualizing in vivo neurovascular remodeling.
- This study offers insights into EA's therapeutic potential for ovarian disorders.
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