A Phosphorylated Zein-Carboxymethyl Chitosan Nanoparticle-Stabilized W/O/W Emulsion: Dual Delivery of Arbutin and Resveratrol for Antioxidant, Whitening, and Transdermal Applications
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View abstract on PubMed
Summary
This summary is machine-generated.Researchers developed a novel W/O/W emulsion using biopolymer nanoparticles for enhanced skin delivery of arbutin and resveratrol. This system offers synergistic transdermal delivery for improved anti-aging and skin brightening topical applications.
Area Of Science
- Cosmetic Science
- Materials Science
- Biotechnology
Background
- Skin aging and UV exposure cause barrier dysfunction and oxidative stress, leading to pigmentation and photoaging.
- Co-delivery of hydrophilic (arbutin) and lipophilic (resveratrol) actives is challenging due to solubility and stability issues.
- Effective topical delivery systems are needed for synergistic anti-aging and skin brightening ingredients.
Purpose Of The Study
- To develop a W/O/W multiple emulsion stabilized by biopolymer nanoparticles.
- To achieve synergistic transdermal delivery of arbutin and resveratrol.
- To create a safe and effective delivery system for skincare applications.
Main Methods
- Formulation of a W/O/W multiple emulsion using phosphorylated zein and carboxymethyl chitosan.
- Encapsulation of arbutin in the internal aqueous phase and resveratrol in zein-based composite colloidal particles.
- Characterization of emulsion properties, antioxidant activity, tyrosinase inhibition, and skin permeation.
Main Results
- High arbutin encapsulation efficiency (up to 94.76%) and strong antioxidant activity (>82% DPPH scavenging).
- Sustained tyrosinase inhibition (>75% after 14 days) and enhanced transdermal delivery (penetration depth ~4861 μm).
- Successful co-delivery of hydrophilic and lipophilic actives via a stable emulsion system.
Conclusions
- Zein-based biopolymer systems can create multifunctional emulsions for synergistic active ingredient delivery.
- The developed W/O/W emulsion shows potential for safe and efficient transdermal delivery in skincare.
- This approach addresses challenges in co-delivering actives with divergent physicochemical properties.
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