Related Experiment Video
Updated: Jan 28, 2026
11:29
miRNA Expression Analyses in Prostate Cancer Clinical Tissues
Published on: September 8, 2015
11.2K
OGDHL Promotes Prostate Cancer Progression and Regulates Neuroendocrine Marker Expression and Nucleotide Abundance
Matthew J Bernard1, Andrea Gallardo2, Angel Ruiz1
1Molecular Biology Interdepartmental Program, University of California, Los Angeles, Los Angeles, California.
Molecular Cancer Research : MCR
|January 27, 2026
Summary
The metabolic enzyme Oxoglutarate Dehydrogenase-Like (OGDHL) unexpectedly regulates prostate cancer growth and treatment resistance. Its loss impairs tumor formation and alters cancer cell identity, suggesting OGDHL as a therapeutic target.
Area of Science:
- Oncology
- Metabolic pathways
- Cancer cell plasticity
Background:
- Aggressive cancers adapt metabolism to evade therapy.
- Prostate cancer develops treatment resistance through lineage plasticity.
- Oxoglutarate Dehydrogenase-Like (OGDHL) is a poorly characterized metabolic enzyme.
Purpose of the Study:
- Investigate OGDHL's role in prostate cancer progression and treatment resistance.
- Determine OGDHL's impact on tumor growth, lineage plasticity, and DNA damage.
- Explore OGDHL as a potential therapeutic target for aggressive prostate cancer subtypes.
Main Methods:
- Genetic manipulation of OGDHL in prostate cancer models.
- Assessment of cell proliferation, tumor formation, and DNA damage markers (ƔH2AX).
- Analysis of OGDHL expression in clinical prostate cancer samples and correlation with neuroendocrine differentiation.
Main Results:
- OGDHL loss impairs prostate cancer cell proliferation and tumor growth.
- OGDHL deficiency reduces nucleotide synthesis and induces DNA damage.
- OGDHL expression correlates with neuroendocrine prostate cancer and its knockdown inhibits tumor growth.
Conclusions:
- OGDHL is an unexpected regulator of prostate cancer growth, lineage plasticity, and DNA damage.
- OGDHL's role in nucleotide metabolism is independent of the tricarboxylic acid (TCA) cycle and mitochondrial localization.
- OGDHL represents a potential therapeutic vulnerability in treatment-resistant, neuroendocrine prostate cancer.
Related Concept Videos
02:40The Eukaryotic Promoter Region
18.7K
The eukaryotic promoter region is a segment of DNA located upstream of a gene. It contains an RNA polymerase binding site, a transcription start site, and several cis-regulatory sequences. The proximal promoter region is located in the vicinity of the gene and has cis-regulatory sequences and the core promoter. The core promoter is the binding site for RNA polymerase and is usually located between -35 and +35 nucleotides from the transcription start site. The distal promoter regions are...
18.7K
02:24Regulation of Expression Occurs at Multiple Steps
26.4K
Gene expression can be regulated at almost every step from gene to protein. Transcription is the step that is most commonly regulated. This involves the binding of proteins to short regulatory sequences on the DNA. This association can either promote or inhibit the transcription of a gene associated with the respective sequence.
Transcription results in the generation of precursor (pre-mRNA) that consists of both exons and introns, which needs further processing before being translated to a...
Transcription results in the generation of precursor (pre-mRNA) that consists of both exons and introns, which needs further processing before being translated to a...
26.4K
03:03mTOR Signaling and Cancer Progression
4.7K
The mammalian target of rapamycin or mTOR protein was discovered in 1994 due to its direct interaction with rapamycin. The protein gets its name from a yeast homolog called TOR. The mTOR protein complex in mammalian cells plays a major role in balancing anabolic processes such as the synthesis of proteins, lipids, and nucleotides and catabolic processes, such as autophagy in response to environmental cues, such as availability of nutrients and growth factors.
The mTOR pathway or the...
The mTOR pathway or the...
4.7K
02:14GTPases and their Regulation
9.8K
Guanine nucleotide-binding proteins (G-proteins), also known as GTPases, are a superfamily of proteins that regulate many cellular processes, such as cell signaling, vesicular transport, and the regulation of cell shape and motility. Mutation or dysfunction of these proteins can lead to disease. There are around 40,000 known G-proteins that can broadly be classified into two groups ‒ small G-proteins consisting of a single domain and large multi-domain G-proteins.
Large G-proteins,...
Large G-proteins,...
9.8K
01:23Regulation of Expression at Multiple Steps
1.4K
The gene expression in cells is regulated at different stages: (i) transcription, (ii) RNA processing, (iii) RNA localization, and (iv) translation. Transcriptional regulation is mediated by regulatory proteins such as transcription factors, activators, or repressors—these control gene expression by initiating or inhibiting the transcription of genes. Once a precursor or pre-mRNA is produced, it undergoes post-transcriptional modification, including 5' capping, splicing, and the...
1.4K
01:42What is Gene Expression?
196.4K
Overview
Gene expression is the process in which DNA directs the synthesis of functional products, that is, proteins. Cells can regulate gene expression at various stages. It allows organisms to generate different cell types and enables cells to adapt to internal and external factors.
Genetic Information Flows from DNA to RNA to Protein
A gene is a stretch of DNA that serves as the blueprint for functional RNAs and proteins. Since DNA is made up of nucleotides and proteins consist of amino...
Gene expression is the process in which DNA directs the synthesis of functional products, that is, proteins. Cells can regulate gene expression at various stages. It allows organisms to generate different cell types and enables cells to adapt to internal and external factors.
Genetic Information Flows from DNA to RNA to Protein
A gene is a stretch of DNA that serves as the blueprint for functional RNAs and proteins. Since DNA is made up of nucleotides and proteins consist of amino...
196.4K