Related Experiment Video
Updated: Jan 28, 2026
10:30
Whole Body and Regional Quantification of Active Human Brown Adipose Tissue Using 18F-FDG PET/CT
Published on: April 1, 2019
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Relationship between epicardial adipose tissue and coronary function evaluated with [13 N]NH3 PET/CT
Francesco Dondi1, Mattia Bertoli2, Pietro Bellini2
1Nuclear Medicine, ASST Spedali Civili di Brescia and Università degli Studi di Brescia, Brescia, 25123 , Italy. francesco.dondi@unibs.it.
The International Journal of Cardiovascular Imaging
|January 27, 2026
Summary
Epicardial adipose tissue (EAT) volume and thickness are linked to reduced myocardial flow reserve (MFR). Increased EAT is an independent predictor of impaired MFR, suggesting EAT influences coronary function.
Area of Science:
- Cardiology
- Radiology
- Biomedical Imaging
Background:
- Epicardial adipose tissue (EAT) is increasingly recognized for its association with cardiovascular disease.
- Previous studies suggest EAT impacts coronary function, myocardial ischemia, and adverse cardiac events.
- The relationship between EAT volume (EATvol) and thickness (EATthick) and myocardial blood flow (MBF) and myocardial flow reserve (MFR) requires further elucidation.
Purpose of the Study:
- To investigate the association between EAT volume and thickness and myocardial blood flow and reserve.
- To determine if EAT parameters are independent predictors of MFR and MBF.
- To explore the influence of EAT on coronary function using [13N]ammonia PET/CT.
Main Methods:
- Retrospective analysis of 164 patients undergoing [13N]ammonia PET/CT.
- Quantification of EAT volume (EATvol) and thickness (EATthick) from unenhanced CT images.
- Extraction of myocardial blood flow (MBF) and myocardial flow reserve (MFR) from PET/CT images.
Main Results:
- Reduced MFR was observed in 30 subjects.
- Both EATvol and EATthick were significantly different between subjects with normal and impaired MFR (p<0.001 and p<0.005, respectively).
- EATvol, age, and diabetes were independent predictors of MFR (p=0.008, p=0.036, and p=0.029, respectively). EATvol and diabetes were also predictors in patients without CAD history.
Conclusions:
- Epicardial adipose tissue volume is correlated with impaired myocardial flow reserve.
- EAT may play a significant role in influencing coronary function.
- EATvol is an independent predictor of MFR, highlighting its clinical relevance in cardiovascular assessment.
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