Comparison of MP-3 Microperimetry and Humphrey 10-2 for Central Visual Field Testing in Mild Glaucoma

The MP-3 CII program may be useful for assessing central visual field function in mild-stage glaucoma, particularly in settings where direct structure-function mapping is desired.

This cross-sectional study aimed to evaluate the performance of the newly developed MP-3 Central Goldmann size II program by comparing its central visual field sensitivity measurements with those obtained from the Humphrey Field Analyzer 10-2 SITA-Standard in patients with preperimetric and mild-stage glaucoma.

This study included 35 eyes from 26 patients with mild-stage glaucoma with macular ganglion cell analysis of optical coherence tomography abnormalities. All participants underwent comprehensive ophthalmologic examinations, including Humphrey Field Analyzer (HFA) 10-2 SITA-Standard and MP-3 Central Goldmann size II visual field testing. The MP-3 Central Goldmann size II program employs a smaller Goldmann II stimulus size and a reduced number of test points compared to the HFA 10-2 SITA-Standard to enhance the detection of subtle central visual field defects.

The MP-3 Central Goldmann size II demonstrated a significantly shorter examination time compared to the HFA 10-2 SITA-Standard (278.8±45.1 seconds vs. 331.7±64.1 seconds, P<0.05). For the measurement points common to both programs, a positive correlation was observed between the two devices in hemifields corresponding to ganglion cell analysis abnormalities (Spearman's rank correlation coefficient, R=0.86; P<0.05) and in the hemifield corresponding to normal ganglion cell analysis (R=0.57; P<0.05).

The MP-3 Central Goldmann size II program showed strong correlation with HFA 10-2 SITA-Standard in measuring central visual field sensitivity.