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Types of Receptors: Internal Receptors

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Internal Receptors

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Related Experiment Video

Updated: Jan 29, 2026

The Ex Vivo Colon Organ Culture and Its Use in Antimicrobial Host Defense Studies

The Ex Vivo Colon Organ Culture and Its Use in Antimicrobial Host Defense Studies

Published on: February 13, 2017

C-Type Lectin Receptors in Host Defense.

Sonja I Gringhuis¹, Teunis B H Geijtenbeek¹

¹Department of Experimental Immunology; Amsterdam Institute for Immunology and Infectious Diseases, Amsterdam UMC, University of Amsterdam, Amsterdam, The Netherlands;

Annual Review of Immunology

|January 27, 2026

Summary

This summary is machine-generated.

C-type lectin receptors (CLRs) on myeloid cells initiate immune responses to pathogens and cell damage. Understanding CLR signaling mechanisms can help treat infectious, autoimmune, and malignant diseases.

Keywords:

C-type lectin receptors adaptive immune response cell death immunity innate immune response microbial defense signal transduction

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Lectin-based Isolation and Culture of Mouse Embryonic Motoneurons

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Last Updated: Jan 29, 2026

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Visualization of Gut Microbiota-host Interactions via Fluorescence In Situ Hybridization, Lectin Staining, and Imaging

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Lectin-based Isolation and Culture of Mouse Embryonic Motoneurons

Lectin-based Isolation and Culture of Mouse Embryonic Motoneurons

Published on: September 15, 2011

Area of Science:

Immunology
Cell Biology
Molecular Biology

Background:

C-type lectin receptors (CLRs) are key regulators of innate and adaptive immunity.
These receptors are strategically positioned to detect microbial components and endogenous danger signals.

Purpose of the Study:

To review the signaling mechanisms linking CLR engagement to cellular responses.
To explore how CLR signaling fine-tunes host-protective immunity and can lead to pathological conditions.

Main Methods:

Literature review of CLR signaling pathways.
Analysis of molecular interplay between CLRs and other pattern recognition receptors.

Main Results:

CLR engagement triggers tailored cellular responses to perceived threats.
Cross-talk between CLRs and other receptors modulates immune outcomes.
Dysregulated CLR signaling can contribute to autoimmune and malignant disorders.

Conclusions:

Understanding CLR regulation offers therapeutic strategies for diverse diseases.
Targeting CLR pathways may provide novel treatments for infectious diseases, autoimmunity, and cancer.