Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Concept Videos

Ionic Crystal Structures02:42

Ionic Crystal Structures

17.0K
Ionic crystals consist of two or more different kinds of ions that usually have different sizes. The packing of these ions into a crystal structure is more complex than the packing of metal atoms that are the same size.
Most monatomic ions behave as charged spheres, and their attraction for ions of opposite charge is the same in every direction. Consequently, stable structures for ionic compounds result (1) when ions of one charge are surrounded by as many ions as possible of the opposite...
17.0K
Protein and Protein Structure02:15

Protein and Protein Structure

87.4K
Proteins are one of the most abundant organic molecules in living systems and have the most diverse range of functions of all macromolecules. Proteins may be structural, regulatory, contractile, or protective. They may serve in transport, storage, or membranes; or they may be toxins or enzymes. Their structures, like their functions, vary greatly. They are all, however, amino acid polymers arranged in a linear sequence.
A protein's shape is critical to its function. For example, an enzyme...
87.4K
Structure-Activity Relationships and Drug Design01:28

Structure-Activity Relationships and Drug Design

1.8K
Drug design is a dynamic field that involves discovering and developing new medications based on specific biological targets. This process heavily relies on structure-activity relationships (SAR) and quantitative structure-activity relationships (QSAR) to guide the design and optimization of efficient drugs.
SAR studies the intricate relationship between a drug's chemical structure and biological activity. It focuses on understanding how modifications to a drug's structure can influence...
1.8K
Structural Properties and Dimensions of Lumber01:21

Structural Properties and Dimensions of Lumber

397
Wood's structural properties derive from fibers aligned along the tree's length, contributing significantly to its mechanical strength. Wood exhibits up to twenty times greater tensile strength along these fibers compared to across them, and generally shows better performance under compression than tension. The length of fibers varies, with hardwoods having fibers around one twenty-fifth inch long and softwoods ranging from one-eighth to one-third inch.
The strength characteristics of...
397
Structure and Physical Properties of Alkynes02:37

Structure and Physical Properties of Alkynes

13.2K
Introduction:
In nature, compounds containing both carbon and hydrogen are known as "hydrocarbons". Aliphatic hydrocarbons are compounds whose molecules contain saturated single bonds (i.e., alkanes) or unsaturated double or triple bonds. Alkenes contain carbon–carbon double bonds and have a structural formula CnH2n. Unsaturated hydrocarbons containing carbon–carbon triple bonds are called "alkynes" and are structurally represented by the formula CnH2n-2.
The...
13.2K
Local Anesthetics: Chemistry and Structure-Activity Relationship01:30

Local Anesthetics: Chemistry and Structure-Activity Relationship

6.6K
Local anesthetics (LAs) are drugs that induce a temporary loss of sensation in a limited body area, preventing pain. Cocaine was the first local anesthetic discovered in the late 19th century. Cocaine is a benzoic acid ester obtained from the leaves of coca shrubs and was often used for its psychotropic effects. Cocaine was first isolated in 1860 by Albert Niemann. Sigmund Freud studied the physiological actions of cocaine. Carl Koller later introduced it into clinical practice in 1884 as a...
6.6K

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

Extracting host-specific developmental signatures from longitudinal microbiome data.

PLoS computational biology·2026
Same author

Benchtop NMR signal enhancement of metabolites in urine extract using SABRE.

Chemical communications (Cambridge, England)·2026
Same author

Tuning ester derivatives of organosolv <i>vs.</i> technical lignin for improved thermoplastic materials.

Faraday discussions·2025
Same author

Detection and resolution of sub-millimolar concentration amino acids on a benchtop NMR spectrometer by nh-PHIP hyperpolarization.

Chemical communications (Cambridge, England)·2025
Same author

Detection of Adenosine Phosphates in Blood by nh-PHIP.

Analytical chemistry·2025
Same author

Nuclear Magnetic Resonance and Computational Studies of Sodium Ions in an Ionic Liquid/Water Mixture.

The journal of physical chemistry. B·2025

Related Experiment Video

Updated: Jan 29, 2026

Investigating Protein Sequence-structure-dynamics Relationships with Bio3D-web
09:51

Investigating Protein Sequence-structure-dynamics Relationships with Bio3D-web

Published on: July 16, 2017

16.0K

Protic Ionic Liquid-H2O Mixtures─Structure, Interactions, and Structure-Property Relationships.

Liisa-Maria Kaljusmaa1, Katarzyna Maria Dziubinska-Kuehn2, Balázs Erdös3

  • 1Department of Energy Technology, Tallinn University of Technology, Ehitajate tee 5, Tallinn 19086, Estonia.

The Journal of Physical Chemistry. B
|January 27, 2026
PubMed
Summary

Understanding protic ionic liquid (PIL) and water mixtures is key for better property prediction. Water

More Related Videos

Correlative Microscopy for 3D Structural Analysis of Dynamic Interactions
13:43

Correlative Microscopy for 3D Structural Analysis of Dynamic Interactions

Published on: June 24, 2013

14.5K
Pretreatment of Lignocellulosic Biomass with Low-cost Ionic Liquids
10:42

Pretreatment of Lignocellulosic Biomass with Low-cost Ionic Liquids

Published on: August 10, 2016

18.9K

Related Experiment Videos

Last Updated: Jan 29, 2026

Investigating Protein Sequence-structure-dynamics Relationships with Bio3D-web
09:51

Investigating Protein Sequence-structure-dynamics Relationships with Bio3D-web

Published on: July 16, 2017

16.0K
Correlative Microscopy for 3D Structural Analysis of Dynamic Interactions
13:43

Correlative Microscopy for 3D Structural Analysis of Dynamic Interactions

Published on: June 24, 2013

14.5K
Pretreatment of Lignocellulosic Biomass with Low-cost Ionic Liquids
10:42

Pretreatment of Lignocellulosic Biomass with Low-cost Ionic Liquids

Published on: August 10, 2016

18.9K

Area of Science:

  • Physical Chemistry
  • Materials Science

Background:

  • Protic ionic liquids (PILs) are versatile solvents with tunable properties.
  • Water's role in PILs can range from impurity to essential co-solvent, significantly impacting mixture behavior.
  • Accurate structure-property relationship models are crucial for optimizing PIL applications.

Purpose of the Study:

  • To investigate the physicochemical properties of low-toxic alkanolammonium- and carboxylate-based PIL-water mixtures.
  • To elucidate the molecular-level distribution and interactions of water within PIL structures.
  • To determine critical aggregation concentrations (CAC) and understand their dependence on mixture composition.

Main Methods:

  • Experimental determination of density, viscosity, and electrical conductivity.
  • Calculation of derived properties such as thermal expansion coefficients and excess molar volumes.
  • Utilized 1D and 2D nuclear magnetic resonance (NMR) spectroscopy to probe water distribution.
  • Determined CAC using physicochemical measurements and 1H longitudinal relaxation times.

Main Results:

  • Water-PIL interactions are primarily governed by the PIL's anion, influencing interaction strength.
  • The PIL's cation dictates the spatial arrangement and location of water molecules within the solvent network.
  • Physicochemical properties and NMR data revealed distinct behaviors of PIL-water mixtures.
  • Critical aggregation concentrations were successfully determined, correlating with interaction strengths.

Conclusions:

  • The study provides a detailed molecular understanding of protic ionic liquid-water mixtures.
  • Findings enhance the ability to predict properties and optimize the design of PIL-based systems.
  • Highlights the importance of considering water's role in PIL applications and development.