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Interface-Engineered Janus Au@CeO2 Nanostructures for Ultrasensitive Ratiometric SERS Platforms.

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Summary

This study introduces novel Janus nanoparticle arrays for enhanced surface-enhanced Raman scattering (SERS) sensing. These arrays achieve superior hotspot control and sensitivity, enabling ultra-low detection limits for bacterial sensing.

Keywords:
Janus structure nanoparticlesbacterial detectionmetal–semiconductor interface hotspotsnanogap spacing regulationsurface-enhanced Raman scattering

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Area of Science:

  • Nanotechnology
  • Materials Science
  • Analytical Chemistry

Background:

  • Monolayer noble metal nanoparticle (NP) arrays are promising for surface-enhanced Raman scattering (SERS) substrates.
  • Controlling hotspot intensity and density is crucial for practical SERS applications.

Purpose of the Study:

  • To develop a SERS substrate with precisely regulated hotspots using Janus-structure NPs.
  • To enhance SERS performance and enable sensitive bacterial detection.

Main Methods:

  • Fabrication of Janus nanostructures by depositing cerium oxide (CeO2) onto gold nanorods (Au NRs).
  • Utilizing 4-mercaptophenylboronic acid (MPBA) as a multifunctional ligand for interparticle spacing regulation and recognition.
  • Construction of a SERS sensor for Escherichia coli detection.

Main Results:

  • Janus NP arrays provide accessible metal-semiconductor interface hotspots and tunable nanogaps (~1 nm).
  • SERS enhancement factor increased over 11 times compared to conventional Au NR arrays.
  • Developed a SERS sensor with an ultralow detection limit of ~1.1 CFU/μL for E. coli.

Conclusions:

  • Janus NP arrays offer a versatile strategy for next-generation SERS substrates.
  • The developed substrate demonstrates high sensitivity and specificity for bacterial detection.