Effects of Differing Nutritional Supplementation Combined With High-Intensity Aerobic Interval Training on Functional...

The aim of the study was to compare the effects of two nutritional supplementation strategies Amendcor (creatine, D-ribose, coenzyme Q10, and vitamin E) versus biquinol+D-ribose, combined with a 12-wk group-based high-intensity aerobic interval training on functional exercise capacity, health-related quality of life, left ventricular ejection fraction, and perceived exertion, in patients with heart failure with reduced ejection fraction.

Sixty-eight patients with heart failure with reduced ejection fraction were randomly assigned to a creatine + D-ribose + CoQ10 + Vit. E ( n  = 35) or a ubiquinol + D-ribose group ( n  = 33) and performed group-based high-intensity aerobic interval training. The primary outcome was functional exercise capacity, assessed via the 6-min walk test, peak VO₂, and peak respiratory exchange ratio. Secondary outcomes included health-related quality of life, left ventricular ejection fraction, and perceived exertion.

Study participants supplemented with creatine + D-ribose+ CoQ10 + Vit. E demonstrated significantly greater improvements in functional exercise capacity (6-min walk test: +19.88%, VO₂ peak: +25.46%, perceived exertion: -38.53%), health-related quality of life: -25.64%, left ventricular ejection fraction: +40.94%, compared with subjects supplemented with ubiquinol + D-ribose ( P  < 0.05).

Patients with heart failure with reduced ejection fraction who received multi-ingredient supplementation combined with group-based high-intensity aerobic interval training demonstrated superior improvements in functional exercise capacity, health-related quality of life, left ventricular ejection fraction, and perceived exertion, compared with those supplemented with ubiquinol + D-ribose.