Related Experiment Video
Updated: Jan 29, 2026

Author Spotlight: Evaluating the Adjuvant Efficacy and Safety of Angong Niuhuang Pill in Viral Encephalitis Treatment
Published on: April 19, 2024
Efficacy of internet-based cognitive behavioral therapy on somatic symptom disorder and common related functional
Shengyi Liu1, Yinghong Li2, Zihua He1
1Department of Neurology, West China Hospital, Sichuan University, Chengdu, China.
Introduction:
Cognitive behavioral therapy (CBT) is recommended for somatic symptom disorder (SSD) and functional somatic syndromes. Face-to-face CBT is limited by accessibility barriers. Internet-based CBT (iCBT) addresses the aforementioned limitations. This study aimed to evaluate the efficacy of iCBT in SSD and common functional somatic syndromes.
Methods:
A meta-analysis was conducted, following the PRISMA statement for study screening. Databases including PubMed, Embase, and CENTRAL. The primary outcomes included somatic symptoms and health anxiety. Secondary outcomes included mood-related outcomes, functioning, and sleep.
Results:
A total of 23 studies were included (1746 iCBT-group vs 1553 control-group patients). Post-treatment, iCBT showed no significant effect difference vs. other psychotherapies (Hedges'g [95% CI]: general symptoms = 0.09 [-0.11; 0.28]; health anxiety: = 0.18 [-0.17; 0.52]), but outperformed waitlisting across most symptoms (Hedges'g [95% CI]: general symptoms = 0.30 [0.12; 0.48]; gastrointestinal = 0.62 [0.35; 0.88]; fatigue = 0.47 [0.25; 0.68]; health anxiety = 0.71 [0.26; 1.16]). The effect of iCBT was not significantly different or slightly higher than treatment as usual after treatment (Hedges'g [95% CI]: gastrointestinal = 0.41 [0.23; 0.58]; fatigue = 0.65 [-0.51; 1.82]; fibromyalgia = 0.27 [0.00; 0.55]). The pooled adverse event rate in the iCBT group was 27%, with no serious adverse events reported.
Discussion:
The iCBT is an effective intervention for SSD and common functional somatic syndromes. However, heterogeneity still exists among subtypes, and personalized plans need to be formulated.
More Related Videos
04:33Author Spotlight: Unveiling the Connection Between Sleep Disorders and Cognitive Symptoms in Depression
Published on: April 26, 2024
08:53Randomized, Triple-Blind, and Parallel-Controlled Trial of Transcranial Direct Current Stimulation for Cognitive Rehabilitation after Stroke
Published on: June 6, 2025
Related Concept Videos
Common Respiratory Disorders
Upper respiratory disorders impact the airways above the vocal cords, encompassing areas like the nose, sinuses, and throat. Various conditions fall under this category, including the common cold and allergic rhinitis. These disorders can stem from several causes,...
Intrinsically Disordered Proteins
REM Sleep Behavior Disorder
RBD is significantly associated with...
Disorders of Acid-Base Balance
Respiratory Acidosis and Alkalosis
Respiratory acidosis occurs due to an increase in the partial pressure of carbon dioxide PCO2 in the blood. It often arises from shallow breathing or impaired gas exchange caused by...
Negative and Cognitive Symptoms of Schizophrenia
Negative Symptoms
Negative symptoms of schizophrenia manifest as deficits in normal emotional and behavioral functioning, profoundly impacting daily life. Individuals with schizophrenia often display a flat affect, characterized by a near-total absence of emotional expression,...
Bone Disorders
Bone deposition is also affected by the levels of sex hormones like estrogen and testosterone that promote osteoblast activity and bone matrix synthesis. When the level of these hormones decreases due to aging, it causes a reduction in bone deposition. As a result, bone resorption by osteoclasts...