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Updated: Jan 29, 2026

Nutrient Regulation by Continuous Feeding for Large-scale Expansion of Mammalian Cells in Spheroids
Published on: September 25, 2016
SNX16 functions as a nutrient-sensitive regulator of autophagosomal components recycling
1School of Basic Medicine, Tongji Medical College and State Key Laboratory for Diagnosis and Treatment of Severe Zoonotic Infectious Disease, Huazhong University of Science and Technology, Wuhan, Hubei, China.
Abstract:
In macroautophagy/autophagy, the inner membrane of the autophagosome and its contents are degraded within the autolysosome, while outer membrane proteins are recycled via a process known as autophagosomal components recycling (ACR). ACR is mediated by the recycler complex, powered by dynein-dynactin complexes, and regulated by RAB32-family small GTPases. However, it remains unknown whether ACR is subject to nutrient signal regulation or whether additional molecular components participate in the recycler complex. Our latest research identifies SNX16 as a new component of the recycler complex and reveals that MTORC1 phosphorylates SNX16, enabling SNX16 to function as a nutrient sensor that regulates ACR.
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