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Innovations in skin microphysiological systems for nonclinical testing and FDA modernization.

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Advancements in skin microphysiological systems (MPSs) offer alternatives to animal testing. Technologies like 3D bioprinting and skin organoids model human skin for research and drug development.

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Area of Science:

  • Biotechnology
  • Toxicology
  • Dermatology

Background:

  • Regulatory shifts favor alternatives to animal testing.
  • Innovations in skin microphysiological systems (MPSs) are advancing preclinical research.
  • Three key technologies are emerging: 3D bioprinting, skin organoids, and skin-on-a-chip.

Purpose of the Study:

  • To review the development and applications of advanced skin MPSs.
  • To highlight how these systems model human skin physiology and disease.
  • To discuss their utility in toxicological screening and therapeutic evaluation.

Main Methods:

  • Review of 3D bioprinting, skin organoids, and skin-on-a-chip technologies.
  • Analysis of their capabilities in modeling skin barrier function, immune responses, and disease phenotypes.
  • Examination of their use in toxicological and therapeutic assessments.

Main Results:

  • These MPS platforms effectively replicate complex skin functions and disease models.
  • They show significant utility in toxicological screening and evaluating new therapies.
  • Emerging strategies involve automation and machine learning for high-content screening.

Conclusions:

  • Skin MPSs are crucial for advancing research and preclinical applications, aligning with regulatory changes.
  • These technologies provide robust models for understanding skin biology and disease.
  • Future validation efforts may be guided by OECD test guidelines, with automation enhancing scalability.