Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Concept Videos

Statistical Software for Data Analysis and Clinical Trials01:12

Statistical Software for Data Analysis and Clinical Trials

1.5K
Statistical software is pivotal in data analysis and clinical trials by providing tools to analyze data, draw conclusions, and make predictions. These software packages range from simple data management applications to complex analytical platforms, supporting various statistical tests, models, and simulation techniques. Their significance lies in their ability to handle vast amounts of data with precision and efficiency, enabling researchers to validate hypotheses, identify trends, and make...
1.5K
Decision Making01:20

Decision Making

947
Decision-making is a fundamental cognitive process that involves evaluating alternatives and selecting among them. This process can range from simple choices, such as deciding what to wear, to complex decisions, like choosing a major in college or a career path. The complexity of the decision often dictates the approach we use, which can be broadly categorized into two types: automatic and controlled decision-making.
Automatic decision-making is fast, intuitive, and relies on gut feelings...
947
Proteomics01:33

Proteomics

9.7K
A proteome is the entire set of proteins that a cell type produces. We can study proteomes using the knowledge of genomes because genes code for mRNAs, and the mRNAs encode proteins. Although mRNA analysis is a step in the right direction, not all mRNAs are translated into proteins.
Proteomics is the study of proteomes' function. It involves the large-scale systematic study of the proteome to denote the protein complement expressed by a genome. Scientist Mark Wilkins coined the term...
9.7K
Decision Making: P-value Method01:09

Decision Making: P-value Method

6.9K
The process of hypothesis testing based on the P-value method includes calculating the P- value using the sample data and interpreting it.
First, a specific claim about the population parameter is proposed. The claim is based on the research question and is stated in a simple form. Further, an opposing statement to the claim  is also stated. These statements can act as null and alternative hypotheses:  a null hypothesis would be a neutral statement while the alternative hypothesis can...
6.9K
Avoidance Learning and Learned Helplessness01:14

Avoidance Learning and Learned Helplessness

2.6K
Avoidance learning and learned helplessness are critical concepts in understanding behavioral responses to negative stimuli.
Avoidance learning occurs when an organism learns that a specific behavior can prevent an unpleasant outcome. For example, a student who receives a bad grade may start studying harder to avoid future poor grades. This behavior persists even when the negative outcome is no longer present. Avoidance learning is powerful because it maintains behavior in the absence of the...
2.6K
Continuing Care01:25

Continuing Care

1.9K
Continuing care describes the variety of health, personal, and social services provided over a prolonged period. The need for continuing care is increasing because people are living longer. Many people do not have families or others to care for them. Continuing care is mainly for patients who are disabled, functionally dependent, or suffering from a terminal disease. It is available within institutional settings or in homes. Examples include nursing centers or facilities, assisted living,...
1.9K

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

Comparative genomic analysis of clinically relevant human skin-associated fungi.

Nature communications·2026
Same author

Proteomics reveals spatial and molecular heterogeneities in advanced atherosclerotic carotid artery plaques.

Nature cardiovascular research·2026
Same author

Amino acids partially override inhibitory effects of octreotide on islet hormone secretion in healthy individuals.

The Journal of physiology·2026
Same author

The effect of ghrelin on insulin sensitivity and beta-cell function after sleeve gastrectomy.

American journal of physiology. Endocrinology and metabolism·2026
Same author

Dose-Response Effect of Glucagon on Glucose, Beta-Cell Secretion and Metabolism in Healthy Individuals.

Diabetes, obesity & metabolism·2026
Same author

Author Correction: Regulatory T cells in the mouse hypothalamus control immune activation and ameliorate metabolic impairments in high-calorie environments.

Nature communications·2026
Same journal

Demonstration of a quantum C-NOT gate in a time-multiplexed fully reconfigurable photonic processor.

Nature communications·2026
Same journal

Nonlinear quantum light source with van der Waals ferroelectric NbOX<sub>2</sub> (X = Br, I).

Nature communications·2026
Same journal

Antagonistic histone H2A variants and autonomous heterochromatin formation shape epigenomic patterns in Arabidopsis.

Nature communications·2026
Same journal

The long tail of nitrate pollution in groundwater challenges governance of global water quality.

Nature communications·2026
Same journal

Select microbial metabolites promote tau aggregation in a murine tauopathy model.

Nature communications·2026
Same journal

Warming climate has lengthened global intense tropical cyclone seasons.

Nature communications·2026
See all related articles

Related Experiment Video

Updated: Jan 29, 2026

Author Spotlight: Advancing Alzheimer's Research &#8211; Exploring Early Detection and Multi-Omics Approaches
09:47

Author Spotlight: Advancing Alzheimer's Research – Exploring Early Detection and Multi-Omics Approaches

Published on: December 15, 2023

1.8K

An adaptive, continuous-learning framework for clinical decision-making from proteome-wide biofluid data.

Johannes B Müller-Reif1, Vincent Albrecht2, Vincenth Brennsteiner2

  • 1Department of Proteomics and Signal Transduction, Max Planck Institute of Biochemistry, Martinsried, Germany. jomueller@biochem.mpg.de.

Nature Communications
|January 27, 2026
PubMed
Summary
This summary is machine-generated.

Adaptive Diagnostic Architecture for Personalized Testing by Mass Spectrometry (ADAPT-MS) enables direct interpretation of proteomics data for personalized diagnostics. This framework dynamically retrains classifiers for scalable, real-time clinical applications.

More Related Videos

Constructing and Visualizing Models using Mime-based Machine-learning Framework
06:19

Constructing and Visualizing Models using Mime-based Machine-learning Framework

Published on: July 22, 2025

2.4K
Author Spotlight: Advancing EVtrap for High-Throughput Proteomics in Disease Biomarker Discovery
09:28

Author Spotlight: Advancing EVtrap for High-Throughput Proteomics in Disease Biomarker Discovery

Published on: October 27, 2023

3.7K

Related Experiment Videos

Last Updated: Jan 29, 2026

Author Spotlight: Advancing Alzheimer's Research &#8211; Exploring Early Detection and Multi-Omics Approaches
09:47

Author Spotlight: Advancing Alzheimer's Research – Exploring Early Detection and Multi-Omics Approaches

Published on: December 15, 2023

1.8K
Constructing and Visualizing Models using Mime-based Machine-learning Framework
06:19

Constructing and Visualizing Models using Mime-based Machine-learning Framework

Published on: July 22, 2025

2.4K
Author Spotlight: Advancing EVtrap for High-Throughput Proteomics in Disease Biomarker Discovery
09:28

Author Spotlight: Advancing EVtrap for High-Throughput Proteomics in Disease Biomarker Discovery

Published on: October 27, 2023

3.7K

Area of Science:

  • Biochemistry
  • Computational Biology
  • Clinical Diagnostics

Background:

  • Mass spectrometry (MS)-based proteomics offers deep molecular insights but faces clinical limitations like missing values and static biomarker panels.
  • Current methods often require targeted assay development, hindering direct diagnostic interpretation of discovery-mode data.
  • The need for robust, scalable, and personalized diagnostic tools from proteomic data is critical for clinical translation.

Purpose of the Study:

  • To introduce a novel framework, Adaptive Diagnostic Architecture for Personalized Testing by Mass Spectrometry (ADAPT-MS), for direct diagnostic and prognostic interpretation of individual patient proteomics data.
  • To overcome limitations of missing values, fixed biomarker panels, and targeted assay development in clinical proteomics.
  • To establish a foundation for scalable, real-time, personalized diagnostics directly from proteome-wide data.

Main Methods:

  • ADAPT-MS dynamically retrains simple, robust classifiers using proteins quantified in each sample, eliminating the need for data imputation or fixed panels.
  • The framework was applied to plasma and cerebrospinal fluid datasets across diverse diseases and clinical centers.
  • Statistical models employed are robust, transparent, and generalizable, ensuring reliable classification.

Main Results:

  • ADAPT-MS achieved high performance and generalizability across different datasets and clinical settings.
  • The approach demonstrated the ability of a single proteomic measurement to support multiple diagnostic questions via retrospective cohort matching.
  • Classifications were performed rapidly, with each taking only seconds.

Conclusions:

  • ADAPT-MS enables direct diagnostic and prognostic interpretation of discovery-mode proteomics data at the individual sample level.
  • The framework provides a scalable, real-time, and personalized diagnostic solution from proteome-wide data.
  • This approach has the potential to transform discovery proteomics into a routine clinical tool, enhancing personalized medicine.