Undifferentiated endometrial carcinoma: a case report

Undifferentiated endometrial carcinoma is a solid tumor that originates from endometrial epithelial cells, accounting for approximately 9% of endometrial cancers. Undifferentiated endometrial carcinoma exhibits high invasiveness, is often diagnosed at an advanced stage, and demonstrates poor sensitivity to chemotherapy. Clinical manifestations lack distinct specificity, with the most common symptoms being abnormal uterine bleeding or discharge and lower abdominal pain.

We report the case of a 50-year-old Chinese female individual who was diagnosed with undifferentiated endometrial carcinoma. Surgery was successfully performed; however, on postoperative day 20, she developed fever, dyspnea, pulmonary infection, and renal insufficiency. Computed tomography scan revealed worsening lung metastases and abdominal tumor recurrence. The patient succumbed to respiratory failure on postoperative day 26.

The etiology of undifferentiated endometrial carcinoma remains unclear, and its treatment principles align with those for endometrial carcinoma. Patients with early stage disease should undergo staging surgery, while those with advanced-stage disease should follow the surgical approach for ovarian cancer, aiming to remove as much visible tumor tissue as possible. Advanced-stage patients experience rapid disease progression and typically face short-term mortality, with no highly effective treatment options currently available.