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Breast Cancer and Cardiovascular Risk: The Role of Dyslipidemia, Inflammation and Obesity
Barbara Loboda1, Darko Zdravkovic1,2, Nebojsa Ivanovic1,2
1University Hospital Medical Center "Bežanijska kosa", 11071 Belgrade, Serbia.
Insights
Breast cancer is a leading cause of death for women in Serbia. This review explores the links between breast cancer, metabolic syndrome, and cardiovascular risk factors, highlighting the need for further research.
Area of Science:
- Oncology
- Cardiology
- Endocrinology
Background:
- Cardiovascular diseases, malignancy, and diabetes mellitus are prevalent chronic non-communicable diseases in Serbia.
- Breast cancer is the most frequent cancer among Serbian women, with significant mortality.
- A strong association exists between cardiovascular risk, metabolic syndrome, and breast cancer.
Purpose of the Study:
- To review current clinical and theoretical knowledge on the connection between breast cancer, metabolic syndrome, and cardiovascular risk.
- To synthesize information regarding the interplay of metabolic factors and cancer development.
- To identify gaps in current research.
Main Methods:
- A comprehensive literature search was performed in January 2024.
- Databases searched included PubMed and Google Scholar.
- Cross-referencing was used to identify additional relevant studies.
Main Results:
- Established links between cardiovascular risk factors (inflammation, dyslipidemia, obesity, diabetes mellitus) and breast cancer.
- Metabolic syndrome components are frequently associated with increased breast cancer risk.
- Existing literature supports a multifactorial relationship.
Conclusions:
- A well-documented connection exists between cardiovascular risk, metabolic syndrome, and breast cancer.
- Further multicenter prospective clinical studies are essential.
- Precise pathophysiological mechanisms require elucidation through additional research.
Abstract:
Cardiovascular diseases, malignancy, and diabetes mellitus are the most common chronic non-communicable diseases affecting the population in Serbia. According to The Cancer Registry of the Republic of Serbia, breast cancer is the most common cancer affecting women in Serbia. Every year, 4600 women get diagnosed with BC, and 1600 women die from this disease. Every eighth woman in Serbia is diagnosed with BC. This review aims to summarize clinical and theoretical information about breast cancer, metabolic syndrome and cardiovascular risk connection. The literature search was conducted through PubMed, Google Scholar and cross-references in January 2024. We concluded that although there is a well-established connection between cardiovascular risk, metabolic syndrome, inflammation, dyslipidemia, obesity, diabetes mellitus and breast cancer, more multicenter prospective clinical studies are needed to establish the precise association and pathophysiological mechanisms.
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