Prediction of Pancreatic Islet Yield After Pancreatectomy Using Optical Coherence Elastography
Ekaterina Gubarkova1, Ekaterina Vasilchikova1, Arseniy Potapov1
1Institute of Experimental Oncology and Biomedical Technologies, Privolzhsky Research Medical University, 603950 Nizhny Novgorod, Russia.
Diagnostics (Basel, Switzerland)
|January 28, 2026
Summary
Optical coherence elastography (OCE) quantifies pancreatic stiffness to predict Langerhans islet yield. This method aids intraoperative assessment, identifying optimal tissue for islet isolation after pancreatectomy.
Area of Science:
- Biomedical Engineering
- Surgical Oncology
- Endocrinology
Background:
- Intraoperative pancreatic quality assessment is crucial for Langerhans islet isolation post-pancreatectomy for diabetes treatment.
- Current methods lack quantitative precision in predicting islet yield.
Purpose of the Study:
- To evaluate pancreatic parenchymal stiffness using optical coherence elastography (OCE).
- To investigate OCE as an indicator of Langerhans islet yield after pancreatectomy.
Main Methods:
- Compression OCE was used to measure stiffness (Young's modulus) in 41 human pancreatic specimens.
- Stiffness values were compared between intact parenchyma, fibrosis, and pancreatic ductal adenocarcinoma (PDAC) invasion.
- Stiffness was correlated with isolated islet yield post-collagenase treatment.
Main Results:
- OCE effectively distinguished pancreatic lesions from intact parenchyma.
- Significantly increased stiffness (p < 0.0001) was found in fibrotic or PDAC-invaded tissue.
- Optimal stiffness range (75-150 kPa) identified for efficient islet isolation (≥120 pcs/g).
Conclusions:
- OCE provides rapid, objective intraoperative assessment of pancreatic tissue quality.
- This technique aids in selecting optimal tissue for Langerhans islet isolation.
- OCE enhances prediction accuracy for islet yield during surgery.
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